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活体减弱疫苗在接受甲索或杜皮卢马布治疗的儿童中使用

Julia R Hughes¹, Sino Mehrmal², Sana Habib³

¹Saint Louis University School of Medicine, St. Louis, Missouri, USA.

Pediatric dermatology

|December 11, 2024

概括

像MMRV这样的活体减弱疫苗被安全地给予儿科患者在甲状腺或dupilumab. 这项研究没有发现任何不良事件,这挑战了这些患者不使用活疫苗的广泛建议.

科学领域:

儿科过敏和免疫学
免疫药理学免疫药理学

背景情况:

一般建议不建议在免疫抑制患者中使用活疫苗.
这些建议源于理论上的风险,而不是特定的药物结果.

研究的目的:

评估活体减弱疫苗在接受甲状腺或dupilumab的儿科患者的安全性.
评估在这些免疫调节剂治疗期间使用活疫苗后的临床结果.

主要方法:

在儿科三级中心 (2017-2023) 进行回顾性电子病历审查.
确定的患者接受活体减弱疫苗在特定间隔周围的甲状腺或dupilumab处方.
在免疫接种后六个月内对不良事件的手动图表审查.

主要成果:

确定了313名接受甲状腺和/或dupilumab治疗的儿科患者.
五名患者接受了麻疹,疹,红疹和水 (MMRV) 疫苗,而在dupilumab;四人接受了它,而在甲状腺素.
在接种疫苗后的六个月内,没有记录任何不良事件.

结论:

活体减弱型MMRV疫苗在小组儿科患者中似乎是安全的.
研究结果表明,当前针对这些特定免疫调节剂的患者使用活疫苗的广泛禁忌可能过于谨慎.
需要进一步的研究来证实活疫苗在这个人群中的安全性和有效性.

关键词:

亚托邦性皮肤炎的发生.孩子们的孩子们的孩子们的孩子们.双重复制的马布.活体减弱疫苗可以使用.甲基特雷克萨酸盐的使用方法

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