对EPA空气中毒物监测数据和用于一般人群暴露评估的工具的分析:使用烯酸作为案例研究
Amanda Kramer1, Stephanie Vivanco2, Jennifer Bare1
1Exposure Sciences Practice, ToxStrategies LLC, Katy, Texas, USA.
Journal of the Air & Waste Management Association (1995)
|December 11, 2024
概括
一般人群通过环境空气接触烯酸 (AN) 的程度较低. 很少检测到烯酸,并且很少超过风险水平. 美国环保署 EPA EPA
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 公共卫生 公共卫生
背景情况:
- 烯酸 (AN) 是一个广泛使用的工业单体.
- 美国环保署根据TSCA建议AN进行高优先级风险评估.
- 有限的数据存在于一般人群对AN的暴露,与工人暴露数据形成鲜明对比.
研究的目的:
- 为了描述一般人群通过环境空气接触到AN的情况.
- 评估EPA监测和建模数据对于监管风险评估的适用性.
主要方法:
- 对EPA空气质量系统 (AQS) 监测数据 (2013-2023) 11年的分析.
- 与EPA的2020年AirToxScreen模拟暴露数据进行比较.
- 对ATSDR草案最低风险水平 (MRL) 的AN检测频率和水平的评估.
主要成果:
- 在13%的环境空气样本中,只检测到烯.
- 不到1%的样本超过了ATSDR MRL草案,趋势下降.
- 通过AirToxScreen建模的数据明显低于AQS测量,这表明了潜在的限制.
结论:
- 一般人群从环境空气中接触到的暴露率很低.
- 美国环保署的AQS数据适用于评估一般人群对AN的暴露.
- 在使用AirToxScreen对AN的估计时建议谨慎使用,因为观察到的差异存在.
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