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在结肠癌治疗中使用库尔库的智能聚合物基输送系统:一篇评论

Adithya Jayaprakash Kamath^1,2, Asawari Dilip Donadkar^1,2, Bhagyalakshmi Nair^1,3

¹Department of Pharmacognosy, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, India.

Phytotherapy research : PTR

|December 11, 2024

概括

智能聚合物通过克服吸收不良和不稳定性来增强结肠癌治疗中的黄素输送. 这些FDA批准的材料提供受控释放,改善治疗对恶性组织的疗效.

科学领域:

生物材料科学生物材料科学
在瘤学瘤学.
药物输送系统药物输送系统

背景情况:

黄素表现出显著的抗结肠癌特性,但其生物可用性较差和有针对性的输送.
限制包括吸收率低,不稳定性和瘤部位度不足.
有效的药物输送系统对于增强黄素的治疗潜力至关重要.

研究的目的:

审查智能聚合物的作用,以克服结肠癌的黄素输送挑战.
探索刺激响应的聚合物作为黄素的先进载体.
确定适用于结肠癌治疗的FDA批准的智能聚合物.

主要方法:

通过使用Scopus,PubMed/Medline,Google Scholar和Science Direct进行了全面的文献搜索.
关键词包括"黄素"",结肠癌"",智能聚合物"",刺激反应性聚合物"和"FDA批准的生物材料".
选了专注于基于智能聚合物的黄素输送的临床前和临床研究.

主要成果:

像PLGA,PEG,Eudragit,cyclodextrin和chitosan这样的刺激反应性聚合物显示出对黄素的递送有希望.
这些智能聚合物可以通过环境刺激 (温度,pH,酶) 触发可控的药物释放.
五种经过FDA批准的智能聚合物被选中,证明了在结肠癌中改善黄素输送的潜力.

结论:

智能聚合物有效地解决了黄素在结肠癌治疗中的局限性.
刺激反应性聚合物提供生物相容性,生物降解性和增强药物向性.
经FDA批准的智能聚合物代表了推进基于黄素的结肠癌治疗的可行策略.

关键词:

通过FDA批准的聚合物.结肠癌是什么意思结肠癌是什么意思库尔库明是一种黄素.智能聚合物是一种智能聚合物.刺激反应的聚合物.

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