患有的学龄前儿童的口腔微生物群:一个匹配的病例控制研究
Yao Wu1,2, Guiding Li3, Chang-Hai Lyu4
1Department of Pediatric Dentistry, School and Hospital of Stomatology, Kunming Medical University, Yunnan, China.
Applied microbiology and biotechnology
|December 11, 2024
概括
患有的儿童的唾液pH值较低,并且有不同的口腔细菌,如Fusobacterium和Neisseria. 口腔健康行为显著影响这些微生物差异,为儿科空管理提供了洞察力.
科学领域:
- 口腔微生物学 口腔微生物学
- 儿科牙科 儿科牙科
- 微生物组研究的研究.
背景情况:
- 肆虐的牙呈现为儿童的快速,严重的牙.
- 了解口腔微生物群的差异对于有效的虫管理至关重要.
- 口腔健康行为和唾液pH与脏病的发展有关.
研究的目的:
- 为了研究患有的儿童和没有的儿童之间的口腔微生物群差异.
- 为了识别潜在的唾液或斑块的生物标志物,为肆虐的.
- 探索口腔健康行为与口腔微生物群组成之间的关系.
主要方法:
- 这是一项涉及88名学龄前儿童的病例控制研究.
- 评估唾液pH值,口腔健康行为,以及上性斑块16S rRNA基因测序.
- 微生物特征,唾液pH值和行为数据之间的相关性分析.
主要成果:
- 患有病的儿童的唾液pH值较低,卫生状况较差,糖类零食摄入量较高.
- 在没有的儿童中,Veillonella被丰富,与唾液pH积极相关.
- 富索细菌和尼塞里亚菌在患有的儿童中很丰富,与频繁的糖果消费有关.
- Streptococcus mutans, Porphyromonas gingivalis 和 Bacteroides acidifaciens 被确定为潜在的生物标志物. 这些生物标志物包括:
结论:
- 口腔微生物群的组成在患有病和没有病的儿童之间有显著差异.
- 特定的细菌和唾液pH值可以作为蔓延的指标.
- 肠道微生物群对儿科的影响需要通过队列研究进一步调查.
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