克罗库斯·萨蒂斯 (番石榴) 作为瑞斯佩里对精神分裂症负面症状的辅助:一种随机,双盲,安慰剂对照的试验
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Siamand Mazhar1, Ahmad Shamabadi1, Kimia Kazemzadeh1
1Psychiatric Research Center, Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences.
International clinical psychopharmacology
|December 11, 2024
概括
番石榴补充剂显著改善了慢性精神分裂症患者的负面症状,证明了安全且耐受良好的辅助治疗. 与安慰剂相比,这种天然化合物增强了整体症状减轻.
科学领域:
- 精神病学和行为科学
- 药理学 药理学是指药理学的学科.
- 神经科学是一个神经科学.
背景情况:
- 目前的精神分裂症治疗面临着有效性和副作用的挑战.
- 需要新的治疗策略来治疗慢性精神分裂症.
- 沙法兰显示出潜在的神经保护和抗精神病性质.
研究的目的:
- 调查沙夫兰作为慢性精神分裂症负面症状的辅助治疗的疗效.
- 为了评估石榴对一般精神病理学和总症状得分的影响.
- 评估沙夫兰在这个患者群体中的安全性和耐受性.
主要方法:
- 一个随机,双盲,安慰剂对照试验,涉及56名稳定的慢性精神分裂症门诊患者.
- 参与者在现有的Risperidone治疗之外,接受了沙夫兰 (每天两次15毫克) 或安慰剂.
- 在第4周和第8周,使用阳性和阴性综合征量表 (PANSS) 评估症状严重程度,以及抑郁症和不良影响量表.
主要成果:
- 对负面的,一般的精神病理学和总的PANSS分数观察到显著的时间治疗相互作用效应,有利于沙夫兰.
- 在沙夫兰小组中,在4周和8周观察到PANSS得分的较大降低.
- 在研究结束时,沙夫兰组的负面症状反应率 (25%) 在研究结束时更高 (P = 0.003).
结论:
- 沙法兰是一种安全和耐受的辅助治疗,用于慢性精神分裂症的主要负面症状.
- 番石榴补充剂在改善一般精神病理和整体症状得分方面表现出比安慰剂更高的疗效.
- 这些发现支持了沙夫兰作为治疗精神分裂症治疗的新疗剂的潜力.
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