在一项新的牛皮研究中提高多样性:可见作为临床试验质量改善框架
Andrew Alexis1, Amy McMichael2, Neelam Vashi3
1Department of Dermatology, Weill Cornell Medicine, New York, New York.
JAMA dermatology
|December 11, 2024
概括
"可见"试验成功招募了多样化的牛皮和皮肤颜色的参与者,这表明战略方法可以提高皮肤病学研究中的临床试验多样性.
科学领域:
- 皮肤病学 皮肤病学
- 临床试验 临床试验
- 健康 公平 卫生 公平
背景情况:
- 临床试验中的多样性代表性有限,影响了不同人群对牛皮的理解.
- 牛皮的呈现和负担因皮肤颜色,种族,种族和社会经济地位而异.
- 关于皮肤颜色 (SoC) 的牛皮患者临床反应,遗传学和生活质量的数据有限.
研究的目的:
- 评估VISIBLE试验中使用的创新策略,用于在牛皮临床试验中招募和保留SoC的各种参与者.
主要方法:
- 在VISIBLE试验中,有211名参与者患有中度至重度斑块性牛皮和SoC.
- 招聘使用客观 (色度测量) 和自我报告的种族/族裔措施.
- 创新策略包括多样化的选址,文化能力培训和多语言数据收集.
主要成果:
- 招生速度大约是预期的7倍.
- 百分之百的参与者自我认同的种族/种族,而不是白人.
- 超过50%的人患有菲茨帕特里克皮肤类型IV-VI,这表明皮肤色调较深的代表.
结论:
- "可见"试验成功地解决了 SoC 牛皮病患者的数据缺口.
- 有意的策略可以加快招聘,提高皮肤病学研究的多样性.
- 这些发现旨在改善临床护理,并为未来的多样性最佳实践提供信息.
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