条件性疼痛调制的个体差异与下降的抗痛感途径中的功能连接有关
Janet Z Li1,2, Emily P Mills1, Natalie R Osborne1,2
1Division of Brain, Imaging, and Behaviour, Krembil Brain Institute, University Health Network, Toronto, ON, Canada.
Pain
|December 11, 2024
概括
疼痛调制的个体差异,特别是受条件疼痛调制 (CPM),与大脑连接性有关. 在下降的抗性感受路径 (DAP) 中的功能连接 (FC) 预测了个体减少疼痛的能力.
科学领域:
- 神经科学是一个神经科学.
- 疼痛研究 疼痛研究
- 心理学 心理学 心理学
背景情况:
- 疼痛感知和应对在个人之间有很大差异.
- 有条件的疼痛调制 (CPM) 涉及抑制性 (反感受性) 和促进性 (前感受性) 过程.
- 单个CPM差异可能与下降抗受体通路 (DAP) 内的功能连接 (FC) 有关.
研究的目的:
- 调查CPM能力的个体变化是否与DAP的关键节点中的FC强度相关.
- 测试一种假设,即抑制性CPM被FC反映在子前带状皮质 (sgACC),周水管灰色 (PAG) 和面向腹中中枢髓 (RVM) 中.
主要方法:
- 采用基于热量的CPM模式.
- 休息状态功能磁共振成像 (rs-fMRI) 用于评估大脑连接.
- 151名健康参与者 (72名男性,79名女性) 完成了CPM测试和rs-fMRI.
主要成果:
- 出现了三种CPM概况:反感 (45%),没有CPM (15%) 和前感 (40%).
- 抗受体组在sgACC和PAG之间,以及RVM和PAG之间显示出显著的FC.
- 服用抗毒感应剂的参与者也显示了sgACC-RVM FC和CPM效应大小之间的相关性. 女性比男性更容易出现预先怀孕.
结论:
- 在DAP中的FC,特别是涉及sgACC,PAG和RVM,与抑制性CPM有关.
- 这些发现表明,DAP中的大脑连接有助于个人抑制疼痛的能力.
- 性差异可能会影响CPM中预感性倾向.
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