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使用心脏生物标志物评估由环素诱导的心脏毒性:一项前性研究
Krishna Prasad1, Budhi Singh Yadav2, Deepy Zohmangaihi3
1Department of Cardiology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Indian journal of cancer
|December 11, 2024
概括
生物标志物N-终端亲B型尿素 (NT-proBNP) 和心脏热素-T (hs-cTnT) 可以预测接受 antracyclines 的癌症患者的早期心脏毒性. 监测这些生物标志物有助于预防未来的心脏事件.
科学领域:
- 在瘤学瘤学.
- 心脏病学 心脏病学
- 生物标志物研究 生物标志物研究
背景情况:
- 人环素是重要的化疗药物,但具有心脏毒性的风险.
- 在治疗中,密切监测患者是必不可少的.
- 早期发现心脏毒性对于治疗癌症患者至关重要.
研究的目的:
- 评估NT-proBNP和hs-cTnT在早期心脏毒性预测中的作用.
- 为了评估这些生物标志物在乳腺和卵巢癌患者接受环素治疗.
主要方法:
- 单中心观察研究 (2018年8月 - 2020年1月).
- 德克索鲁比辛每次循环使用50mg/m2.
- 在基线和化疗后3,6,12个月进行心声学.
- 在基线和第一个和最后一个化疗周期后测量NT-proBNP和hs-cTnT.
主要成果:
- 包括72名患者 (91.7%为乳腺癌);12.5%患有心脏毒性.
- 在心脏毒性患者的化疗后观察到显著升高的NT-proBNP和hs-cTnT水平.
- 心脏毒性组的平均年龄为55.00±12.5岁.
结论:
- 测量NT-proBNP和hs-cTnT可以有效地检测亚临床心脏毒性.
- 早期发现有助于治疗方案的修改.
- 启动心力衰竭治疗可以预防未来的心脏事件.
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