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Updated: Jun 5, 2025

Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods
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Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods

Published on: July 17, 2019

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SRC激酶驱动由KRAS-G12C抑制诱导的多药耐药性

Xinxin Song1, Zhuan Zhou1, Ammar Elmezayen2

  • 1Department of Surgery, UT Southwestern Medical Center, Dallas, TX 75390, USA.

Science advances
|December 11, 2024
PubMed
概括

克拉斯-G12C抑制剂在癌症中面临抗药性. 将SRC抑制剂与这些药物结合起来,通过向JUN-ABCC1通路来克服耐药性,从而提高治疗疗效.

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