在患有急性呼吸道病理的儿童中,抗氧化剂系统的动态指标取决于治疗方案
Olesya M Horlenko1, Iryna Yu Pikina1, Lyubomyra B Prylypko1
1UZHHOROD NATIONAL UNIVERSITY, UZHHOROD, UKRAINE.
概括
这项研究研究了急性呼吸道感染儿童的抗氧化剂系统,发现优化治疗改善了谷氨过氧化酶,酸和维生素D的水平,以及有益的微量元素变化.
科学领域:
- 儿科肺病学 儿科肺病学
- 免疫学 免疫学 免疫学
- 生物化学 生物化学
背景情况:
- 急性呼吸道感染 (ARI) 在儿童中构成了重大健康挑战.
- 早期诊断和有效的ARI管理对于预防严重后果至关重要.
- 抗氧化剂系统 (AOS) 在儿科ARI中的作用需要进一步阐明.
研究的目的:
- 加强早期诊断和预测儿童ARI的发展.
- 评估抗氧化剂系统状态对ARI过程和结果的影响.
- 在AOS标志物和临床参数上评估优化治疗策略的有效性.
主要方法:
- 研究了一组被诊断为ARI的学龄儿童 (10-14岁) (n=111) 的队列.
- 为了进行比较,包括健康儿童 (n=25) 的对照组.
- 分析了AOS组分 (费里,皮质醇,酸,维生素D) 和炎症标志物 (TNF-α,IL-6,IL-2,γ-IFN) 之间的相关性.
主要成果:
- 在费里和TNF-α,以及皮质醇和氨酸过氧化酶之间观察到显著的正相关性.
- 亚酸与IL-6和IL-2呈现积极的相互作用,而维生素D与γ-IFN,勒和铜相关.
- 优化治疗导致谷氨酸过氧化酶,酸和维生素D水平显著增加,并使维生素D水平正常化,对铜,和铁有积极影响.
结论:
- 抗氧化剂系统在儿科ARI的发病和恢复中起着至关重要的作用.
- 优化的治疗方法显著改善了ARI儿童的AOS状态和临床结果.
- 监测AOS标志物可以帮助儿童呼吸道感染的早期诊断,预后和个性化治疗策略.
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