补充激活档案预测了髓寡细胞糖蛋白抗体与疾病相关的临床结果
Javier Villacieros-Álvarez1, Jan D Lunemann1, Maria Sepulveda1
1From the Neurology-Neuroimmunology Department (J.V.-Á., V.F., A.V., M. Castillo, M. Comabella), Multiple Sclerosis Center of Catalonia, Vall d'Hebron Barcelona Hospital Campus, Vall d'Hebron Research Institute; Autonomous University of Barcelona (M. Comabella), Spain; Department of Neurology with Institute of Translational Neurology (J.D.L.), University Hospital Münster, Germany; Neuroimmunology and Multiple Sclerosis Unit (M.S., S.L., Y.B.), Hospital Clinic de Barcelona; Fundación INCE (Iniciativa para las Neurociencias) (A.V.-C.), Madrid, Spain; Neurology Unit (A.D., S.M.), Department of Neurosciences, Biomedicine, and Movement Sciences, University of Verona, Italy; Neuroimmunology Program (S.L., Y.B., T.A.), Neurology Service, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic de Barcelona; Pediatric Neuroimmunology Unit (T.A.), Neurology Department, Sant Joan de Déu Children's Hospital, University of Barcelona; Girona Neuroimmunology and Multiple Sclerosis Unit (G.Á.B., L.R.), Neurology Department, Dr. Josep Trueta University Hospital and Santa Caterina Hospital; Neurodegeneration and Neuroinflammation research group (G.Á.B., A.Q.-V., L.R.), IDIBGI, Girona-Salt; Department of Medical Sciences (G.Á.B., L.R.), Faculty of Medicine, University of Girona; and Redes de Investigación Cooperativa Orientada a Resultados en Salud (RICORS) (A.Q.-V., L.R.), Red de Enfermedades inflamatorias (RD21/0002/0063), Instituto de Salud Carlos III, Madrid, Spain.
补充因子 (CFs) 在氨酸寡腺细胞糖蛋白抗体相关疾病 (MOGAD) 中显示出诊断和预后价值. 血清CF区分MOGAD与MS和AQP4-NMOSD,而CSFCF预测复发和残疾.
科学领域:
- 神经免疫学 神经免疫学
- 补充系统生物学 补充系统生物学
- 生物标志物发现发现
背景情况:
- 在MOGAD中补充系统的作用尚未完全理解.
- 缺乏MOGAD的诊断和预后生物标志物.
- 补充因子 (CF) 在MOGAD中被调查其潜力.
研究的目的:
- 研究MOGAD患者中CF的诊断和预后价值.
- 为了比较MOGAD,MS和AQP4-NMOSD中的CF水平.
- 在MOGAD中评估CF与复发和残疾结局的关联.
主要方法:
- 多中心回顾性队列研究.
- 包括患有MOGAD,MS和AQP4-NMOSD的患者与配对的血清和CSF样本.
- 测量CFs使用多重ELISA和统计分析用于诊断和预后评估.
主要成果:
- 血清C3a,C4a和C3a/C3比率有效地区分了MOGAD与MS和AQP4-NMOSD (AUC分别为0.95和0.88).
- 脑脊液补充剂水平,特别是C4和C4a/C4比率,与MOGAD中的复发风险和频率有关.
- 在MOGAD患者中,增加的CSFSC5b9水平与增加的残疾相关 (EDSS ≥3.0).
结论:
- 补充因子的血清和脑液水平在MOGAD中显示出显著的诊断和预后效用.
- 这些发现支持补充剂抑制剂作为MOGAD治疗策略的潜力.
- 肺结核代表了MOGAD诊断和结果预测的有希望的生物标志物.
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