纳米酶作为瘤能量恒温破坏剂,以增强级联催化疗法
Xingchen Li1, Xia Zhang2, Lei Song3
1State Key Laboratory of Supramolecular Structure and Material, College of Chemistry, Jilin University, Changchun 130012, China.
一种新的纳米酶破坏了瘤能量平衡,结合了饥饿,化学动力学和光热疗法. 这种方法通过诱导铁亡并增强反应性氧物种的产生,有效地抑制肺癌的生长.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术 纳米技术
- 在瘤学瘤学.
背景情况:
- 瘤微环境调节对于有效治疗肺癌至关重要.
- 需要可持续的策略来破坏瘤能量平衡.
研究的目的:
- 开发一种多功能纳米酶,Cu2O@Au,作为用于协同癌症治疗的"瘤能量平衡破坏剂".
- 研究纳米酶在饥饿疗法,化学动力学疗法 (CDT) 和光热疗法 (PTT) 的疗效.
主要方法:
- 合成了Cu2O@Au纳米酶,并对类似葡萄糖氧化酶和类似过氧化酶的活动进行了表征.
- 这些纳米酶被用于消耗葡萄糖的饥饿疗法和通过产生基基 (•OH) 的CDT.
- 研究了包括谷氨消耗,xCT蛋白抑制,ROS生成,脂质过氧化和铁灭症诱导在内的机制. 还评估了光热性能和成像能力.
主要成果:
- Cu2O@Au纳米酶有效消耗葡萄糖,产生H2O2,并降低瘤的pH值,提高CDT的疗效.
- 这些纳米酶通过耗尽谷氨和抑制囊的吸收来诱导铁亡.
- 实现了饥饿疗法,CDT和PTT的协同效应,导致显著的瘤生长抑制. 该纳米酶还展示了CT和光热成像能力.
结论:
- Cu2O@Au纳米酶作为有效的瘤能量稳态破坏者,为协同肺癌治疗提供了一个有前途的战略.
- 多功能纳米酶整合了饥饿疗法,CDT和PTT,展示了显著的治疗潜力和未来癌症疗法的宝贵见解.
更多相关视频
08:19Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo
Published on: July 20, 2019
07:48Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures
Published on: December 26, 2016
相关概念视频
Adaptive Mechanisms in Cancer Cells
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Electron Transport Chain: Complex I and II
ROS generation is regulated and maintained at moderate levels necessary...
Targeted Cancer Therapies
There are several types of targeted therapies against...
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
