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慢速低剂量口服免疫治疗牛奶后的长期结果
Yoshito Matsuo1, Shiro Sugiura2, Seiya Masukane2
1Department of Allergy, Allergy and Immunology Center, Aichi Children's Health and Medical Center, Aichi, Japan, sbqxg502@yahoo.co.jp.
International archives of allergy and immunology
|December 11, 2024
概括
慢速低剂量口服免疫疗法 (SLOIT) 帮助了三分之一的儿童患有严重的牛病.
科学领域:
- 过敏和免疫学 过敏和免疫学
- 儿科胃肠病学 儿科胃肠病学
背景情况:
- 严重的牛奶过敏 (CMA) 对受影响的儿童构成重大挑战.
- 慢慢低剂量口服免疫疗法 (SLOIT) 是对严重CMA的一年治疗方案.
- SLOIT涉及一种严重程度分层的方法,逐渐增加牛奶 (CM) 摄入量.
研究的目的:
- 评估SLOIT在患有严重CMA的儿童的长期结果.
- 在完成SLOIT协议后,确定与成功脱敏相关的因素.
- 评估实现对CM.完全脱敏的速度.
主要方法:
- 对23名完成SLOIT协议并继续增加CM摄入量 (SLOIT-plus) 的儿童进行了后续研究.
- 评估了12个月,24个月和36个月对200毫升CM全剂量 (FD) 脱敏的受试者的比例.
- 量化过敏症状严重程度使用阿纳菲拉克斯评分艾契 (ASCA) 总得分 (TS) 和TS/累积蛋白质剂量 (TS/Pro).
主要成果:
- 在SLOIT后的36个月内,35% (8/23) 的儿童实现了对全剂量CM.的脱敏.
- 达到全剂量 (FD) 的组与非FD响应者相比,TS/Pro,CM特异性IgE和素的减少更大.
- 没有孩子在12个月达到FD,而13% (3/23) 在24个月达到FD.
结论:
- 大约三分之一的严重CMA儿童可以在SLOIT协议后的三年内实现对CM的完全脱敏.
- 对1年SLOIT协议的更好的初始反应与改善的长期结果和降低敏感性有关.
- 在儿童群体中,SLOIT为严重的牛奶过敏提供了一种可行的长期治疗策略.
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