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在患有不明原因慢性咳的患者中,外周气道的抵抗性增加
Ewa Ternesten-Hasséus1,2, Ewa-Lena Johansson3,4, Eva Millqvist1,2
1Department of Respiratory Medicine and Allergology, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Respiration; international review of thoracic diseases
|December 11, 2024
概括
与健康个体相比,无法解释的慢性咳 (UCC) 患者表现出较高的周围呼吸道阻力和降低FEV1%的预测值. 整合脉冲振荡计 (IOS) 和螺旋计有助于UCC诊断.
科学领域:
- 肺部病理学 肺部病理学
- 呼吸系统医学 呼吸系统医学
- 临床研究 临床研究
背景情况:
- 无法解释的慢性咳 (UCC) 被定义为没有明确原因或有效治疗的持续性咳 (>8周).
- 评估大和小气道功能对于理解UCC病理生理学至关重要.
- 脉冲振荡计 (IOS) 和螺旋计是评估气道功能的关键工具.
研究的目的:
- 为了比较UCC患者的大小气道功能与健康对照组,使用IOS和螺旋计.
- 调查UCC患者的潜在触发因素和症状严重程度.
- 评估结合IOS和螺旋计在UCC中的诊断实用性.
主要方法:
- 50名UCC患者和23名健康对照人接受了IOS和螺旋计.
- 此外,UCC患者还测量了部分呼出的氧化 (FeNO),并填写了有关症状和生活质量的问卷.
- 收集了咳触发因子 (化学物质,冷空气,运动) 和视觉模拟量表 (VAS) 评分的数据.
主要成果:
- 与对照组相比,UCC患者表现出较高的周围气道阻力和反应能力,以及较低的FEV1%预测值.
- 患有UCC的女性比患有UCC的男性有更大的呼吸道阻力和反应能力.
- 常见的触发因素包括化学物质暴露 (98%),冷空气 (78%) 和运动 (76%).
结论:
- UCC与周围气道阻力增加和FEV1%预测值降低有关.
- 常规的肺功能测试,包括IOS和螺旋计,可以提高UCC诊断.
- 进一步的研究可能会阐明UCC中特定的气道功能障碍模式.
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