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T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

658
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
658
Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

519
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
519

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相关实验视频

Updated: Jun 5, 2025

Transnuclear Mice with Pre-defined T Cell Receptor Specificities Against Toxoplasma gondii Obtained Via SCNT
13:36

Transnuclear Mice with Pre-defined T Cell Receptor Specificities Against Toxoplasma gondii Obtained Via SCNT

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在T切换的TCR特异性.

Andrew Y Hu1, Cristina Puig-Saus2

  • 1Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at the University of California Los Angeles (UCLA), Los Angeles, CA, USA; Division of Surgical Oncology, Department of Surgery, David Geffen School of Medicine at the University of California Los Angeles (UCLA), Los Angeles, CA, USA.

Immunity
|December 11, 2024
PubMed
概括
此摘要是机器生成的。

研究人员从非自我反应的T细胞中设计了自我反应的T细胞受体 (TCR). 这一进展显示了开发针对自我抗原的T细胞免疫疗法的潜力.

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Streamlined Single Cell TCR Isolation and Generation of Retroviral Vectors for In Vitro and In Vivo Expression of Human TCRs
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Retroviral Transduction of Bone Marrow Progenitor Cells to Generate T-cell Receptor Retrogenic Mice
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相关实验视频

Last Updated: Jun 5, 2025

Transnuclear Mice with Pre-defined T Cell Receptor Specificities Against Toxoplasma gondii Obtained Via SCNT
13:36

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Streamlined Single Cell TCR Isolation and Generation of Retroviral Vectors for In Vitro and In Vivo Expression of Human TCRs
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科学领域:

  • 免疫学 免疫学 免疫学
  • 分子生物学分子生物学
  • 生物技术是生物技术.

背景情况:

  • 中央耐受性是一种关键的免疫机制,可以防止T细胞攻击身体自身的组织 (自我抗原).
  • 开发T细胞疗法通常需要克服自然的自我耐受机制.

研究的目的:

  • 开发一种产生自我反应性T细胞受体 (TCR) 的方法.
  • 探索具有这些新型TCRs的工程T细胞在免疫治疗中的潜力.

主要方法:

  • 利用定向进化来修改非自动反应的TCRs.
  • 工程TCRs识别特定的自我抗原.

主要成果:

  • 通过定向进化成功生成了自我反应的TCR.
  • 在临床前模型中证明了用这些TCRs设计的T细胞的潜力.

结论:

  • 描述的方法提供了一种创新的方法来创建自我反应的TCR.
  • 具有这些TCRs的工程T细胞对未来针对自我抗原的免疫疗法策略具有前景.