多发性硬化症中的光学连贯性断层扫描:一个突尼斯的三级中心研究研究
I Zone-Abid1, K Maaloul1, N Hamza2
1Department of Ophtalmology, Habib Bourguiba University Hospital, Faculty of Medicine of Sfax, University of Sfax, Sfax, Tunisia.
Journal francais d'ophtalmologie
|December 11, 2024
概括
光学连贯断层扫描 (OCT) 显示多发性硬化症 (MS) 患者的视网膜层显著变薄,与临床和视觉唤起潜力 (VEP) 测量相关. 这突出了海外国家和地区的特点.
科学领域:
- 眼科和神经科学 眼科和神经科学
- 神经退行性疾病研究研究
背景情况:
- 多发性硬化症 (MS) 是中枢神经系统的慢性炎症性脱髓化疾病.
- 视网膜神经退行越来越被认为是MS的特征,可能作为生物标志物.
- 光学连贯断层扫描 (OCT) 允许视网膜层的体内成像,提供一种非侵入性方法来评估神经轴损伤.
研究的目的:
- 在MS患者中使用光谱域OCT调查视网膜层厚度.
- 探索来自OCT的视网膜测量与MS的临床 (EDSS) 和电生理学 (VEP) 特性之间的相关性.
- 评估OCT作为一种用于量化MS神经退行症的工具的潜力.
主要方法:
- 横截面研究涉及51名多发性硬化患者 (18-60岁) 和30名年龄/性别匹配的健康对照.
- 评估包括神经检查 (EDSS),眼科检查,光谱域OCT和视觉唤起潜力 (VEP).
- 分析的重点是围状视网膜神经纤维层 (pRNFL) 和质细胞内状层 (GCIPL) 的厚度.
主要成果:
- 与对照组相比,多发性硬化患者的pRNFL厚度显著减少 (P<0.001).
- 观察到内层 (IPL),内核层 (INL) 和外层 (OPL) 厚度的显著减少.
- pRNFL和GCIPL缩与多发性硬化-视神经炎 (MS-ON) 的病史和更高的EDSS分数有显著的相关性.
- 在VEP中,pRNFL缩与视敏度相关,并增加了P100波延迟.
- 在初级渐进性多发性硬化症中保留了prNFL,但在复发性复发性和二级渐进性形式中缩.
结论:
- OCT是量化MS患者神经退行的一个有价值的工具.
- 视网膜层缩,特别是PRNFL和GCIPL,与MS的临床残疾和电生理变化有关.
- 海洋和海上国家的测量可以帮助监测多发性硬化症患者的疾病进展和治疗反应.
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