婴儿发作综合征:当发作突然出现时
Marta Conti1, Sara Matricardi2, Ludovica M Piscitello1
1Child Neurology, Epilepsy and Movement Disorders, Bambino Gesù, IRCCS Children's Hospital, Full Member of European Reference Network EpiCARE, Rome, Italy.
Epilepsy & behavior : E&B
|December 11, 2024
概括
在以前正常的儿童中,婴儿发作综合征 (IESS) 在及时治疗的情况下显示出有利的结果. 早期的发作自由和正常发育预测了这个IESS亚组的良好长期预后.
科学领域:
- 神经学 神经学
- 儿科神经学 儿科神经学
- 发病学 (Epileptology) 是一个专业的学科.
背景情况:
- 婴儿发作综合征 (IESS) 可以在以前正常发育的儿童中出现.
- 在这种特定的IESS子组中确定结果的预测因素对于临床管理至关重要.
研究的目的:
- 评估IESS在正常发育前的儿童中的电临床特征.
- 描述临床结果并确定有利预后的独立预测因素.
主要方法:
- 来自意大利两个中心的43名同质IESS患者的回顾性分析,正常发育前发病.
- 排除具有危险因素,其他类型的发作,大脑异常或已知的遗传疾病的患者.
- 标准化EEG评估,使用BASED评分进行间触模式的评估.
主要成果:
- 大多数患者 (65.11%) 在发病时表现出轻微的行为变化.
- 在EEG上,性脑病 (EE) 的流行率为 (清醒率:69.76%,睡眠率:81.40%).
- 实现了迅速的自由 (83.72%在15天内),主要是使用ACTH储存;所有患者在六个月内都没有和EE.
- 在最后一次随访时,81.40%的人具有正常的认知功能,而其他人则有语言障碍.
结论:
- 一个独特的IESS患者小组具有正常的先前发展,表现出迅速的治疗反应和有利的长期结果.
- 缺乏严重的神经发育影响和持续的自由性是这一子组的特征.
- 在IESS发病前的正常发育和早期治疗反应是良好的预后的关键预测因素.
更多相关视频
10:22Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy
Published on: December 6, 2016
20.2K
06:58Non-restraining EEG Radiotelemetry: Epidural and Deep Intracerebral Stereotaxic EEG Electrode Placement
Published on: June 25, 2016
19.1K
相关概念视频
01:13Seizures: Classification
300
Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
300
01:24Arteries of the Lower Limbs
177
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
177
01:16Vascular Spasm
1.2K
The vascular phase, also known as vasospasm, is the initial stage of hemostasis, crucial for preventing excessive bleeding when a blood vessel is injured. After a vessel is cut, nerves in the damaged area trigger pain and other sensory impulses. Simultaneously, the smooth muscles in the vessel wall contract, resulting in a vascular spasm. This contraction reduces the vessel's diameter at the injury site, slowing or stopping blood loss through the vessel wall. Vascular spasms typically last...
1.2K
01:29Spasmolytic Agents: Chemical Classification
857
Spasmolytic agents are drugs used to alleviate muscle spasms and spasticity. They can be categorized into different chemical groups based on their mechanisms of action. Centrally acting spasmolytics primarily affect the spinal cord, while others directly target skeletal muscle cells.
A major class of centrally acting spasmolytics is the α2-agonist, such as tizanidine. These drugs bind to α2-adrenoceptors, inhibiting the release of the excitatory neurotransmitter glutamate. They also...
A major class of centrally acting spasmolytics is the α2-agonist, such as tizanidine. These drugs bind to α2-adrenoceptors, inhibiting the release of the excitatory neurotransmitter glutamate. They also...
857
01:22Somatic Spinal Reflexes
1.8K
Somatic spinal reflexes are rapid, involuntary muscular responses to external stimuli that involve the somatic musculature and the spinal cord.
One of the most well-known somatic spinal reflexes is the stretch reflex, which is activated by the sudden stretching of a muscle. This reflex involves the activation of specialized sensory receptors called muscle spindles, which are located in the muscle tissue and detect changes in the length and speed of muscle contractions. When a muscle is suddenly...
One of the most well-known somatic spinal reflexes is the stretch reflex, which is activated by the sudden stretching of a muscle. This reflex involves the activation of specialized sensory receptors called muscle spindles, which are located in the muscle tissue and detect changes in the length and speed of muscle contractions. When a muscle is suddenly...
1.8K
01:20Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein
248
Antiepileptic drugs, such as levetiracetam (Keppra) and brivaracetam (Briviact), have emerged as crucial tools in managing epilepsy. These medications exert their therapeutic effects by targeting the synaptic vesicle protein SV2A, a transmembrane glycoprotein primarily found in the brain.
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
248