海的免疫细胞和相关的微生物群与氧化铁纳米颗粒共同接触,激活细胞和分子重编程,促进生理适应
Andi Alijagic1, Roberta Russo2, Viviana Scuderi3
1Man-Technology-Environment Research Center (MTM), Örebro University, Örebro SE-701 82, Sweden.
Journal of hazardous materials
|December 11, 2024
概括
氧化铁纳米粒子 (Fe-oxide NPs) 与海的免疫细胞和微生物群相互作用,促使细胞变化和微生物转移. 这种反应有助于恢复免疫系统的平衡.
科学领域:
- 环境科学环境科学
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
背景情况:
- 天生的免疫系统是对纳米材料的主要反应器.
- 微生物群和天生的免疫在调节免疫恒温的相互作用还不太清楚.
研究的目的:
- 研究氧化铁纳米颗粒 (Fe-oxide NPs),免疫细胞和微生物群的同时相互作用.
- 探索氧化铁NP对免疫系统和海Paracentrotus lividus中相关微生物群落的影响.
主要方法:
- 使用了体外-外生态微生物群/免疫细胞模型.
- 采用拉曼光谱,16S下一代测序,高内容成像和NanoString nCounter分析.
主要成果:
- 氧化铁NP诱导免疫细胞重组并保持细胞健康,而无需显著激活细胞死亡标志物.
- 观察到免疫细胞中的转录基因重编程和不变的关键免疫信号通路.
- 检测到细胞外囊泡的增加和微生物组成的转变有利于格拉姆阳性细菌.
结论:
- 氧化铁NP触发了复杂的,涉及免疫细胞和微生物群的多层次反应.
- 这种反应似乎恢复了海模型中的免疫平衡.
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