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解构小鼠社会层次结构的基础神经电路

Qiuhong Xin¹, Diyang Zheng², Tingting Zhou²

¹Department of Neurobiology, Affiliated Mental Health Center & Hangzhou Seventh People's Hospital and School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China; Nanhu Brain-Computer Interface Institute, MOE Frontier Science Center for Brain Science and Brain-Machine Integration, State Key Laboratory of Brain-Machine Intelligence, New Cornerstone Science Laboratory, Zhejiang University, Hangzhou 311121, China.

|December 11, 2024

概括

背中前额叶皮层 (dmPFC) 通过不同的神经通路控制社会竞争. 特定的dmPFC神经元促进获胜,而其他神经元抑制失败,揭示了社会行为调节的关键机制.

科学领域:

神经科学是一个神经科学.
动物行为动物行为
社会层次结构社会层次结构.

背景情况:

社会竞争建立了等级地位,影响了动物的健康和行为.
背中前额叶皮层 (dmPFC) 对于调节社会竞争至关重要.
对于dmPFC控制的特定下游神经回路来说,对于赢/输行为并没有很好地理解.

研究的目的:

识别和描述dmPFC下游的独特神经通路,这些神经通路调节社会竞争.
为了阐明dmPFC如何通过自上而下的控制来编排与胜负相关的行为.

主要方法:

全脑c-Fos映射以识别活跃的神经元.
纤维光度测量用于在体内监测神经活动.
光遗传学和化学遗传学用于有针对性的神经元操纵.
在体内和体外电生理学记录.

主要成果:

识别了dmPFC下游的解剖学分离的神经通路.
在dmPFC5层中,神经元向背脊拉菲核 (DRN) 和周水管灰色 (PAG) 突出的神经元促进竞争.
dmPFC层2/3向前底侧杏仁体 (aBLA) 投射的神经元抑制竞争.
在竞争期间,这些通路中的对立活动变化以及它们之间的抑制相互作用.

结论:

该dmPFC利用不同的,解剖学上分离的途径来促进和抑制社会竞争.
赢得促进和丧失抑制途径之间的对抗性相互作用是dmPFC对社会行为的控制的核心原则.
这种自上而下的控制机制对于编排复杂的社会行为至关重要.

关键词:

基本侧面的杏仁体背面的拉菲核核.中部前额叶皮层中部前额叶皮层社会竞争社会竞争在社会竞争中社会层次结构社会层次结构.试管测试试管测试试管测试试管测试

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