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早期生命微生物群的殖民化通过调节巨细胞中NGF的产生来调节 nociceptor的敏感性

Nasser S Abdullah¹, Amyaouch Bradaia¹, Manon Defaye¹

¹Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB, T2N4N1, Canada; Inflammation Research Network, Snyder institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB, T2N4N1, Canada; Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, T2N4N1, Canada.

Mucosal immunology

|December 11, 2024

概括

早期的肠道微生物群殖民通过影响巨细胞中的神经生长因子 (NGF) 生产来调节疼痛敏感性,从而影响整个生命中的感觉受体功能.

科学领域:

神经科学是一个神经科学.
微生物学微生物学
免疫学免疫学免疫学

背景情况:

肠道微生物群影响生理过程,包括疼痛敏感性.
生命早期是微生物群和 nociceptors 的发展的关键窗口.
生命早期微生物群和 nociceptor 发育之间的相互作用仍然不太清楚.

研究的目的:

研究肠道微生物群在生命早期的殖民化对 nociceptor 敏感性的作用.
阐明微生物群调节疼痛感知的机制.
确定巨细胞和神经生长因子 (NGF) 在这个过程中的参与.

主要方法:

使用无细菌和 gnotobiotic 的小鼠模型.
评估了对热和素刺激的感觉敏感性.
分析了TRPV1的贩运,巨细胞降粒和NGF的表达.
研究了早期殖民时间和巨细胞抑制的影响.

主要成果:

没有细菌的小鼠表现出疼痛敏感性降低,这与TRPV1贩运量降低和较低的乳腺细胞NGF水平有关.
早期的殖民 (出生时) 恢复了正常的感受器敏感性,而断奶后的殖民却没有.
在生命早期抑制巨细胞降粒或NGF信号,导致成人过敏症.

结论:

早期的肠道微生物群殖民对于建立正常的感受器敏感性至关重要.
微生物群通过巨细胞NGF生产在生命早期关键的窗口中调节 nociceptor 灵敏度.
这些发现表明微生物向干预治疗疼痛的潜力.

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