在Omicron变种占主导地位的浪潮期间,增强疫苗接种和COVID-19后的状况:一项基于人口的大型研究
Arisa Iba1, Mariko Hosozawa1, Miyuki Hori1
1Institute of Global Health Policy Research, Bureau of International Health Cooperation, National Center for Global Health and Medicine, Shinjuku, Tokyo, Japan.
概括
提升COVID-19疫苗接种可能会降低COVID-19后疾病 (PCC) 的风险. 感染前接受三剂或更多剂量的人,特别是女性,PCC概率较低,神经症状较少.
科学领域:
- 流行病学 流行病学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 后COVID-19条件 (PCC) 提出了长期的挑战,其预防,特别是关于强剂疫苗接种,需要进一步调查.
- 奥米克朗变种浪潮凸显了需要了解疫苗接种时间和剂量对PCC风险的影响.
研究的目的:
- 评估COVID-19强剂疫苗接种状态和时间与患PCC的风险之间的关联.
- 调查增强剂对特定PCC症状的影响,包括呼吸道和神经症状.
主要方法:
- 一项基于人口的研究分析了在Omicron波中感染的COVID-19患者 (20-69岁).
- 倾向性得分和逆概率加权后勤回归被用于评估疫苗接种状态 (未接种疫苗,1-2剂量,≥3剂量) 和PCC风险.
- 多变量后勤回归分析了疫苗接种时间,按性别分层分析和症状类型的子组分析.
主要成果:
- 在7936名参与者中,11.8%的人患有PCC.
- 与未接种疫苗相比,在感染前接种三剂或更多剂的疫苗与PCC概率降低有关 (OR:0.69,95%CI:0.53至0.90).
- 这种保护作用在女性中被观察到,并且与较少的神经症状 (OR:0.61,95% CI:0.45-0.83) 相关,但不是呼吸系统症状. 对于一次或两次剂量,没有发现任何关联.
结论:
- 补充疫苗接种,特别是三剂或更多剂量,似乎可以降低COVID-19后疾病的风险.
- 这些发现表明,增强免疫接种在缓解长期后病毒综合征,特别是神经症状方面具有潜在的益处.
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