溶解微针阵列补丁含有不同孔径尺寸的中孔纳米颗粒作为可调节的持续释放平台
Juan L Paris1, Lalitkumar K Vora2, Ana M Pérez-Moreno3
1Allergy Research Group, Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND. RICORS "Enfermedades inflamatorias", Málaga, Spain; School of Pharmacy, Queen's University Belfast, Medical Biology Centre, Belfast, UK.
International journal of pharmaceutics
|December 11, 2024
概括
溶解带有中孔纳米颗粒的微针阵列补丁提供了一种无痛药物输送的新方法. 这项研究证明了它们在皮肤内的有效插入,溶解和持续的货物释放.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 皮肤病学 皮肤病学
背景情况:
- 溶解微针阵列贴片 (DMAP) 有助于通过皮肤输送治疗药物.
- 将DMAP与纳米颗粒结合起来,通过持续释放来提高治疗效果.
- 半孔纳米粒子 (MSN) 是多功能药物载体,由于可调节的孔径大小.
研究的目的:
- 开发和表征 DMAP 结合半孔纳米粒子 (MSN).
- 评估这些DMAPs的体外,体外和体内性能,以通过皮肤输送.
- 为了确认纳米颗粒沉积和微针插入后的体内货物释放.
主要方法:
- 制造含有不同孔径大小的MSN的DMAP,在尖端集中.
- 在体外,体外和体内插入研究使用帕拉菲尔姆,新生猪皮肤和小鼠模型.
- 用光标记的MSN被用于跟踪皮肤中的沉积和释放.
- 在体内光测量评估了从小鼠皮肤中的纳米颗粒释放的货物.
主要成果:
- 一种新的方法成功地产生了大约2.3毫克MSN的DMAP.
- 在所有测试模型中证实了DMAPs的成功插入和溶解.
- 量化了MSN的皮内沉积 (20.9 ± 7.26%在猪皮).
- 在小鼠身上成功地证明了存储的MSN的体内货物释放.
结论:
- 装有MSN的DMAP代表了有效和无痛的通过皮肤递送药物的有希望的平台.
- 开发的方法允许控制沉积和持续释放治疗有效载荷.
- 这项技术具有各种治疗应用的潜力,需要在皮肤上有针对性和长时间的药物作用.
相关概念视频
01:23Factors Affecting Dissolution: Particle Size and Effective Surface Area
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are employed to...
01:19Modified-Release Drug Delivery Systems: Rate-Programmed II
Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
01:30Modified-Release Drug Delivery Systems: Stimuli-Activated
Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...