怀孕结果在2型糖尿病:一个系统的审查和元分析
Naomi S Clement1, Ahmad Abul2, Rachel Farrelly1
1Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK.
American journal of obstetrics and gynecology
|December 11, 2024
概括
与1型糖尿病,妊娠期糖尿病和非糖尿病妊娠相比,怀孕期间的2型糖尿病 (T2D) 导致婴儿怀孕年龄较小的风险更高,先天异常和围产死亡率更高. 提高意识对于改善母亲和婴儿的结果至关重要.
科学领域:
- 产科和妇科 产科和妇科
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 2型糖尿病 (T2D) 在英国的怀孕中越来越普遍.
- 了解与怀孕期间T2D相关的特定风险对于临床管理至关重要.
研究的目的:
- 为了比较T2D女性与1型糖尿病 (T1D),妊娠期糖尿病 (GDM) 和非糖尿病怀孕女性的怀孕结果.
- 为了确定怀孕期间与T2D相关的不良结果.
主要方法:
- 从2009年1月到2024年,在PubMed上进行了系统的文献搜索.
- 符合条件的研究包括至少有十次T2D怀孕的队列观察研究,将结果与T1D,GDM或非糖尿病怀孕进行比较.
- 分析的主要结局是先天性异常,死胎,死亡率,出生体重,LGA,SGA和宏观体.
主要成果:
- 与T1D相比,T2D怀孕的SGA,新生儿和围产期死亡率较高.
- 与GDM相比,T2D怀孕有先天性异常,LGA,新生儿死亡率和死胎的风险增加.
- 与非糖尿病妊娠相比,T2D与更高的先天性异常,LGA,围产死亡率和死胎率有关.
结论:
- 怀孕期间的2型糖尿病与与其他形式的糖尿病相比,产前期的结果明显更差.
- 提高医疗保健提供者和政策制定者对T2D不良妊娠结果的认识,对于改善护理和患者结果至关重要.
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