同型半氨酸与骨关节炎患者全因死亡率之间的关联:来自NHANES数据库的队列研究

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Yu Shi¹, Minan Lu¹, Feng He¹

¹Department of Orthopedic Surgery, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme

|December 11, 2024

概括

高水平的homocysteine (Hcy) 与骨关节炎患者的全因死亡率增加有关,特别是在特定的亚组中. 血清Hcy可以作为骨关节炎结果的预后生物标志物.

科学领域:

生物标志物生物标志物
流行病学流行病学
老年学是一门学科.

背景情况:

骨关节炎 (OA) 是一种常见的退行性关节疾病,具有显著的发病率.
血清homocysteine (Hcy) 水平升高已与各种慢性疾病有关,但其在OA死亡率中的预后作用仍在调查中.

研究的目的:

为了研究血清Hcy水平和全因死亡率在美国成年骨关节炎队列之间的关联.
根据Hcy水平确定高死亡风险的OA患者的特定亚组.

主要方法:

一项队列研究利用了1999-2006年国家健康和营养检查调查 (NHANES) 的数据.
血清Hcy水平使用阿博特同类氨酸测定 (FPIA) 进行测量.
使用加权的Cox比例危险模型和受限立方线来分析Hcy与全因死亡率之间的关联,调整共变量并进行子组分析.

主要成果:

这项研究包括1384名OA患者,到2019年12月,有817人 (59.03%) 死亡.
在对共变量进行调整后,高血清Hcy水平与OA患者所有原因死亡率的增加显著相关 (HR=1.31,95%CI:1.02-1.67).
这种关联在女性,60岁以上的个体,OA持续时间>10年,高血压史,没有糖尿病史,C反应蛋白 (CRP>0.29 mg/l) 升高的人群中尤为明显.

结论:

高血清Hcy水平是骨关节炎患者全因死亡的重要风险因素.
血清Hcy显示出作为一个有价值的预后生物标志物来预测OA患者群体的死亡风险的承诺.
进一步的研究可能会阐明在OA中Hcy-死亡率联系背后的机制,并告知有针对性的干预措施.

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