与抗Tr/DNER抗体相关的神经神经综合征呈现带膜脑炎与无细胞大细胞淋巴瘤:一个病例报告
Shintaro Fujii1, Hiroaki Yaguchi1, Ikuko Takahashi-Iwata1
1Department of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan.
Internal medicine (Tokyo, Japan)
|December 11, 2024
概括
一名老年男子因抗Tr/Delta-Notch类表皮生长因子相关受体 (DNER) 抗体而患上边缘性脑炎 (LE). 这种罕见的呈现与形大细胞淋巴瘤有关,而不是典型的霍奇金淋巴瘤.
科学领域:
- 神经学 神经学
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 自身免疫性边缘性脑炎 (LE) 是一种罕见的神经疾病.
- 与表皮生长因子相关受体 (DNER) 的反Tr/Delta-Notch类抗体通常与小脑缩症和霍奇金淋巴瘤 (HL) 相关.
研究的目的:
- 报告一种罕见的临界脑炎病例,与抗DNER抗体和形大细胞淋巴瘤相关.
- 突出抗体检测和瘤监测在非典型瘤神经综合征中的重要性.
主要方法:
- 一个82岁的老人患有急性意识障碍的临床表现.
- 磁共振成像 (MRI) 显示双边叶异常.
- 大脑脊髓液 (CSF) 分析揭示了细胞.
- 对抗DNER抗体的血清检测.
- 组织活检用于淋巴瘤诊断.
主要成果:
- 这位患者出现了边缘性脑炎,而不是小脑衰竭.
- 阳性抗DNER抗体测试. 这是一个很好的结果.
- 诊断形大细胞淋巴瘤.
- 这种情况偏离了抗DNER抗体与霍奇金淋巴瘤的典型关联.
结论:
- 自身免疫性边缘性脑炎可能是由抗DNER抗体引起的.
- 无细胞大细胞淋巴瘤是抗DNER抗体相关的神经综合征的罕见并发症.
- 早期的抗体检测和全面的瘤查对于诊断和管理非典型瘤神经综合征至关重要.
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