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功能神经障碍的发生率和患病率:系统性审查

Sara A Finkelstein^1,2, Clare Diamond³, Alan Carson⁴

¹Functional Neurological Disorder Unit, Division of Behavioral Neurology and Integrated Brain Medicine, Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA.

Journal of neurology, neurosurgery, and psychiatry

|December 11, 2024

概括

功能神经障碍 (FND) 影响着每10万人中至少有80-140人. 这一系统性审查强调了需要增加对FND的研究和资金,因为FND的流行程度很高.

科学领域:

神经学神经学
流行病学流行病学
公共卫生公共卫生

背景情况:

功能神经障碍 (FND) 具有显著的症状负担和高的医疗保健利用率.
强大的流行病学数据对于有效的资源分配和对FND的规划至关重要.

研究的目的:

系统地审查和综合有关FND的发病率和流行率的现有数据.
为了更清楚地了解FND对人口的影响.

主要方法:

在PubMed进行了系统的文献搜索,以确定有关FND发生率和流行率的原始研究文章.
对包括的研究进行了偏差风险评估.
估计了发病率和流行率,包括从功能性发作研究的推断.

主要成果:

包括39篇文章,其中19篇报告发生率,21篇报告流行率.
在研究中观察到显著的异质性,这使得直接比较具有挑战性.
估计的FND发病率:10-22/100,000;最低的流行率:80-140/100,000 (范围为50-1600/100,000). 据估计,FND的发病率是10-22/100,000;最低的流行率是80-140/100,000 (范围为50-1600/100,000). 儿科FND发病率:1-18 / 100,000. 在儿童中发生的FND发病率:1-18 / 100,000. 在儿童中发生的FND发病率:1-18 / 100,000.

结论:

在FND发病率和流行率估计中存在很大差异,这可能是由于方法上的挑战和低估.
保守的估计表明,在英国至少有50-100,000名患有FND的人.
这些数据强调了需要增加FND计划的研究和临床资金,考虑到其与其他神经系统疾病相比的流行率.

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