阐明自身免疫性疾病和抑郁症之间的双向关联:系统性审查和元分析
Yongli Li1,2,3, Chengyuan Zhao1,2,3, Shihua Sun4
1Department of Gastroenterology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Provincial Lab for Clinical Immunology Translational Medicine in Universities, Jinan, Shandong, China.
BMJ mental health
|December 11, 2024
概括
这一元分析揭示了抑郁症和自身免疫性疾病 (ADS) 之间的显著双向联系. 患有AD或抑郁症的风险在患有其他疾病的人群中显著增加,特别是在老年人和女性中.
科学领域:
- 医学研究 医学研究
- 精神病学是一个精神病学.
- 免疫学 免疫学 免疫学
背景情况:
- 越来越多的证据表明抑郁症和自身免疫性疾病 (ADS) 之间存在联系.
- 关于双向关系和特定患者子组的数据有限.
- 这次元分析解决了集体证据的稀缺问题.
研究的目的:
- 确定ADS患者抑郁症的发病率和相对风险 (RRs).
- 确定抑郁症患者中AD的发病率和RRs.
- 为了研究这些协会在不同的AD小组和人口统计学.
主要方法:
- 在多个数据库 (PubMed,Embase,Web of Science等) 中进行全面的文献搜索. 在2024年9月之前.
- 包括研究ADS和抑郁症之间的纵向风险的队列研究.
- 从47项涉及超过4077万参与者的研究中对发病率和RR进行了聚合分析.
主要成果:
- 在AD患者中,抑郁症的综合发病率为6.71% (RR=1.85),特别是在45岁以上的患者和女性中更高.
- 在患有抑郁症的人群中,AD综合发病率为0.54% (RR=1.84).
- 特定的抗药物,包括内分泌,生殖尿路和皮肤疾病,显示风险增加.
结论:
- 抑郁症和自身免疫性疾病之间存在明显的双向关联.
- 在老年患者和患有AD的女性中观察到抑郁症的相对风险增加.
- 特定的自身免疫性疾病类别对伴随性抑郁症的风险概况更高.
关键词:
抑郁症 抑郁症 抑郁症相关概念视频
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