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Updated: Jun 5, 2025

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions
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对高血蛋白结合化合物的药物相互作用的预测

David Tess1, Makayla Harrison2,3, Jian Lin2

  • 1Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Cambridge, Massachusetts, USA.

The AAPS journal
|December 11, 2024
PubMed
概括

对高度结合的化合物进行准确的药物相互作用 (DDI) 预测,现在可以使用等离子体 (fu,p) 中的实验性未结合分数值. 这种方法尽量减少假阳性,并确保可靠地识别临床DDI风险.

关键词:
药物相互作用 药物相互作用平衡透析透析的方法实验性的 福,p,p.分数没有绑定.高度绑定高度绑定结合等离子体蛋白质的结合.

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