在可溶性微阵列贴片中开发安福特乙含复杂配方,用于阴道内输送
Habiburrahim Burhanuddin1, Cindy Kristina Enggi1, Frederika Tangdilintin1
1Faculty of Pharmacy, Hasanuddin University, Makassar, 90245, Indonesia.
概括
通过使用一种具有β-cyclopodextrin (βCD) 纳入复合物的新型可溶性微阵列贴片 (DMP) 改善了安福特B (AMB) 的溶解性和阴道输送. 这增强了用于治疗 vulvovaginal candidasis 的药物吸收.
科学领域:
- 制药科学 制药科学
- 药物输送系统 药物输送系统
- 菌类学 菌类学是指菌类学.
背景情况:
- 氨酸B (AMB) 对于治疗 vulvovaginal candidasis (VVC) 是至关重要的.
- 由于AMB的口服吸收不佳,其治疗效果受到限制.
- 含有β-cyclopodextrin (βCD) 的复合物增强了AMB的溶解性.
研究的目的:
- 通过βCD纳入复合体来改善AMB的溶解性和生物可用性.
- 开发一种新的可溶性微阵列贴片 (DMP),用于增强AMB的阴道分娩.
- 为了优化DMP配方的药物保留,透和受控释放.
主要方法:
- 分子对接证实了AMB-βCD纳入复合体 (IC) 的稳定性.
- 使用IC,聚乙醇 (PVA) 和聚乙烯罗利 (PVP) 配制的DMP.
- 猪阴道粘膜用于评估DMP的机械强度,插入和刺激;差异扫描热量计 (DSC) 评估了物理化学特性.
主要成果:
- 含有复合物的AMB溶解度增加了多达四倍.
- IC-DMP显示出出色的机械性能和无刺激的插入.
- 配方F3在猪的阴道粘膜中显示出优异的保留率 (AUC:208.02 ± 0.33 h·μg/cm3,Cmax:20.05 ± 0.06 μg/cm3),表明最佳的阴道药物输送.
结论:
- 将IC集成到DMP中显著提高了AMB的溶解性和生物可用性,用于阴道内应用.
- 这种新的DMP系统增强了用于VVC处理的AMB吸收.
- 对于这种有前途的药物输送系统,需要进行进一步的临床研究.
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