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在早产和晚产新生儿中进行鼻内止痛
A Perri1,2, S Fattore3, A Sbordone3
1Department of Woman and Child Health Sciences, Child Health Area, University Hospital Agostino Gemelli, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Lazio, Italy. Alessandro.perri@policlinicogemelli.it.
Paediatric drugs
|December 11, 2024
概括
内鼻药物输送为新生儿疼痛管理提供了优势. 本综述指导婴儿,特别是早产新生儿使用芬太尼,米达佐拉姆,胺和德克斯梅德托米丁等鼻入药物的使用.
科学领域:
- 新生儿护理 新生儿护理
- 药理学 药理学是指药理学的学科.
- 疼痛管理 疼痛管理
背景情况:
- 新生儿疼痛管理是关键的,因为婴儿的不成熟的疼痛系统和增加的应激反应.
- 婴儿未经治疗的疼痛与不良的神经发育结果有关,包括较差的认知和运动分数.
- 内鼻药物输送与口服药物输送相比,具有优势,例如更快的吸收和避免胃肠道影响.
研究的目的:
- 审查关于用于治疗新生儿疼痛的鼻入药物管理的证据.
- 为新生儿群体提供鼻入药物的剂量和适用性提供实用指南.
- 要突出适用于新生儿疼痛和镇静的特定鼻内药物.
主要方法:
- 对治疗新生儿疼痛的鼻内药物输送研究的文献综述.
- 在婴儿中分析常见止痛药的药理动力学和药理动力学.
- 对新生儿使用的特定鼻内药物的现有证据的综合.
主要成果:
- 鼻内芬太尼是一种可行的选择,用于缺乏IV接入的早产婴儿的手术/息性疼痛.
- 鼻内用米达佐拉姆适用于终期/近期新生儿的镇静.
- 胺和德克斯梅托米丁在特定的新生儿镇静和疼痛管理场景中表现有前途,德克斯梅托米丁在早产婴儿中耐受良好.
结论:
- 内鼻药物为新生儿疼痛和镇静提供了有效和实用的替代品.
- 特定的药物,如芬太尼,米达佐拉姆,氨酸和德克斯梅德托米丁在新生儿护理中发挥着不同的作用.
- 进一步的研究和鼻内路线的临床应用可以优化新生儿疼痛管理策略.
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