负面的生活事件和表观遗传衰老:荷兰的一项研究 双胞胎登记册
Bodine M A Gonggrijp1, Steve G A van de Weijer2, Catrien C J H Bijleveld3
1Department of Biological Psychology, Netherlands Institute for the Study of Crime and Law Enforcement (NSCR), Amsterdam, Netherlands. b.m.a.gonggrijp@vu.nl.
Behavior genetics
|December 11, 2024
概括
负面的生活事件,特别是经济困难,加速表观遗传衰老 (GrimAge). 然而,双胞胎研究表明,共同的遗传和环境因素可能会混这些关联,突出强调压力和生物衰老的复杂性.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 老年学是一门学科.
- 心理神经免疫学 心理神经免疫学
背景情况:
- 负面的生活事件与不良的健康结果有关.
- 表观遗传衰老,衰老的生物测量,可能受到环境压力因素的影响.
- 了解这种联系对于公共卫生至关重要.
研究的目的:
- 调查负面生活事件对表观遗传衰老的长期影响.
- 分析各种负面生活事件与五种表观遗传生物标志物之间的关联.
- 通过双胞胎研究来探索家族因素的作用.
主要方法:
- 来自荷兰双胞胎登记册的1783名成年人的分析.
- 对五种表观遗传生物标志物的评估:汉努姆,霍瓦斯,芬诺年龄,格林年龄和杜尼丁PACE.
- 检查包括受害和经济困难在内的负面生活事件,并进行人口层面和双胞胎对分析.
主要成果:
- 更多的负面生活事件,特别是财务逆境,性犯罪和失业,与GrimAge有关.
- 在调整了BMI,吸烟和白细胞计数后,这些关联仍然存在.
- 在对负面生活事件不一致的单胞胎双胞胎中,关联减少了,这表明混的家族因素.
结论:
- 负面的生活事件,特别是财务逆境,与加速表观遗传衰老 (GrimAge) 有关.
- 共享的遗传和环境因素可能会混压力和表观遗传衰老之间的人口水平关联.
- 需要进一步的研究来解开遗传和环境对压力因素和生物衰老之间的关系的影响.
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