塞法林会改变脏的微生物群,从而促进石化环境的形成
Jose Agudelo1,2, Xing Chen3,4, Sromona D Mukherjee5
1Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic, Cleveland, OH, USA. agudelj@ccf.org.
Nature communications
|December 11, 2024
概括
脏含有细菌,这些细菌可以被抗生素改变,影响结石的形成. 这项研究直接证明了脏微生物群及其对常见抗生素的反应.
科学领域:
- 微生物学 微生物学
- 腎臟病學 (nephrology) 是一種醫學.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 尿路微生物组 (urobiome) 可能会影响脏生理,但对脏细菌和抗生素影响的直接证据有限.
- 对于脏细菌的现有证据依赖于间接来源或受感染的组织,抗生素的影响不清楚.
研究的目的:
- 提供脏组织内细菌的直接证据,并研究它们对抗生素的反应.
- 探索氧酸 (CaOx) 结石形成中的微生物群的作用.
- 确定人类脏中的微生物特征及其对脏疾病的潜在影响.
主要方法:
- 直接成像和RNA测序以确定小鼠和人类脏中的细菌存在和.
- 在小鼠中服用塞法林,以评估抗生素对脏微生物群组成的影响和依赖持续时间的影响.
- 在体外分析细菌对氧化结晶的影响.
主要成果:
- 在小鼠脏中,脏微孔内有细菌的直接证据.
- 塞法林治疗改变了脏微生物群,减少了Lactobacillus spp. 并且增加了 Enterobacteriaceae,其效果取决于治疗时间.
- 特定的细菌菌株对氧酸盐晶体形成产生了差异性的影响.
- 独特的微生物特征在人类脏的球体和管中被确定,随年龄而异.
结论:
- 脏有稳定的,对抗生素有反应的微生物群,可以影响结石的形成 (CaOx质生成).
- 抗生素的使用可以显著改变脏微生物群,在停止治疗后有可能恢复.
- 人类脏中的明显的微生物,随着年龄的变化而变化,表明对非传染性脏疾病的影响.
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