抗生素扰乱的微生物群和益生菌的作用
Hania Szajewska1, Karen P Scott2, Tim de Meij3
1Department of Paediatrics, The Medical University of Warsaw, Warsaw, Poland.
Nature reviews. Gastroenterology & hepatology
|December 11, 2024
概括
抗生素会破坏人类的微生物群. 虽然益生菌可以减少腹等副作用,但将其与抗生素治疗后微生物群恢复相关的证据有限,需要进一步研究.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 抗生素显著改变人类微生物群的组成和功能.
- 益生菌被假设可以恢复被抗生素破坏的微生物群,但支持证据有限.
- 观察到益生菌的临床益处,例如减少与Clostridioides difficile相关的腹,但与微生物群恢复的因果关系尚未被证明.
研究的目的:
- 批判性地评估支持使用益生菌在抗生素治疗后恢复微生物群的证据.
- 探索研究抗生素对人类微生物群的影响的复杂性和挑战.
- 审查当前的研究环境,并提出未来的研究方向.
主要方法:
- 审查关于抗生素对人类微生物群的影响现有文献.
- 对缓解抗生素相关副作用的益生菌疗效的临床数据的分析.
- 讨论定义和测量微生物群恢复的挑战.
主要成果:
- 虽然益生菌可以减轻一些与抗生素相关的不良影响,但缺乏直接证据证明它们在保护或恢复抗生素破坏的微生物群中的作用.
- 存在重大挑战,包括定义"正常"的微生物群,标准化微生物组分析,并考虑个人间的变异性.
- 目前的证据基础不足以使益生菌使用与微生物群在抗生素暴露后的恢复有因果关系.
结论:
- 假设益生菌恢复了抗生素破坏的微生物群,需要更强大的科学验证.
- 需要进一步的研究来建立微生物组分析的标准化方法,并定义微生物群的恢复.
- 未来的研究应侧重于建立益生菌干预和微生物群弹性或恢复之间的因果关系.
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