在阻塞性睡眠呼吸暂停中,侧面的上垂体崩与侧面导向的喉崩有关
Tsai-Yu Wang1,2, Phillip Huyett3, Hyungchae Yang1,4
1Division of Sleep and Circadian Disorders, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
在阻塞性睡眠呼吸暂停患者中,侧面喉崩显著增加了侧面表关节崩的风险. 这一发现表明,喉缩模式可能会导致表皮缩,影响呼吸道阻塞.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 睡眠医学 睡眠医学
- 呼吸系统生理学 呼吸系统生理学
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 涉及睡眠期间呼吸道缩.
- 表皮膜崩可能导致气道阻塞,呈前后或侧面.
- 侧面或集中性喉崩可能会重塑上衣,导致侧面崩.
研究的目的:
- 为了调查侧面或同心的喉崩模式是否与侧面的上垂体崩 (E-lat) 相关.
- 为了测试这一假设,横向导向的喉崩会增加并发E-lat.的几率.
主要方法:
- 从药物诱导睡眠内镜队列中分析了582名OSA患者.
- 使用VOTE标准对塌现场进行评分,由单一得分者进行评分.
- 后勤回归来评估喉崩和E-lat之间的关联.
主要成果:
- 侧面表皮塌 (E-lat) 的患病率为2.6% (15名患者).
- 任何侧向的喉倒塌与E-lat (OR 4.4) 的几率增加了4倍.
- 完整的口腔大侧壁崩 (OR 3.4) 和完整的同心软 palatal 崩 (OR 8.6) 与 E-lat 有显著的关联.
结论:
- 严重的侧喉崩,包括同心的软口腔崩或口喉侧壁崩,在患有E-lat.的患者中更为普遍.
- 这些发现支持这个概念,即喉缩模式可能会重塑表.
- 这种重塑可能有助于在OSA中侧面表皮质崩的发病.
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