肠道微生物组和NAFLD:影响和治疗潜力
Liwei Li1, Fuqing Cai1, Chen Guo1
1Department of Gastroenterology, The Second Affiliated Hospital of Guangxi Medical University, Nanning, China.
Frontiers in microbiology
|December 12, 2024
概括
非酒精性脂肪性肝病 (NAFLD) 与肠道微生物群失衡有关. 准肠道细菌,病毒,真菌和寄生虫为NAFLD提供了潜在的治疗策略.
科学领域:
- 胃肠病学和肝病学
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 非酒精性脂肪性肝病 (NAFLD) 影响全球超过30%的人口,代表着严重的健康负担.
- 肠道微生物群,包括细菌,病毒,真菌和寄生虫,越来越多地被认为是NAFLD病原体中的作用.
- 肠道微生物群落中的失生症有助于肝脏脂肪积累和炎症.
研究的目的:
- 审查目前对NAFLD肠道微生物群组成和功能的理解.
- 探索细菌,病毒,真菌和寄生虫对NAFLD发展和进展的影响.
- 讨论针对NAFLD管理的肠道微生物群的潜在治疗干预措施.
主要方法:
- 文献综述综合了关于肠道微生物群和NAFLD的当前研究.
- 对研究细菌失生症,病毒影响,真菌关联 (例如,Candida) 和寄生虫暴露 (卫生假说) 的研究分析.
- 检查治疗策略,包括益生菌,益生菌和便微生物群移植.
主要成果:
- 肠道细菌失生症改变了导致肝脏脂肪积累和炎症的途径.
- 肠道病毒组影响微生物动态和宿主新陈代谢.
- 像Candida这样的特定真菌与NAFLD标志物有不利关联,而减少寄生虫暴露可能会影响免疫和代谢调节.
结论:
- 肠道微生物群在NAFLD中发挥着多方面的作用.
- 针对肠道微生物群的干预措施对NAFLD具有治疗前景.
- 综合性NAFLD管理策略必须考虑肠道微生物生态系统内的复杂相互作用.
相关概念视频
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
316
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
316
What is Monogastric Digestion?
70.6K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
70.6K
Microorganisms in Medicine and Therapeutics
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
Bacterial Flora of the Large Intestine
378
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
378


