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相关概念视频

Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

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Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
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Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

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The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
876
Myasthenia Gravis: Diagnostic Tests01:15

Myasthenia Gravis: Diagnostic Tests

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Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
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相关实验视频

Updated: Jun 5, 2025

Author Spotlight: Advanced Integrated Model for Sepsis-Induced Myopathy and Single-Cell Metabolic Analysis
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Author Spotlight: Advanced Integrated Model for Sepsis-Induced Myopathy and Single-Cell Metabolic Analysis

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免疫检查点抑制剂诱导的肌肉炎导致严重的死:一个病例报告

Nadine A Abdeljabbar1, Sabrina Genovese1, Mohamed B Haradwala1

  • 1Department of Neurology, University of Missouri School of Medicine, Columbia, USA.

Cureus
|December 12, 2024
PubMed
概括

布罗利祖马布可以引起免疫相关的不良事件 (irAEs),如尿路癌患者的,肌炎和心肌炎. 早期检测和使用类固醇和血交换的积极治疗对于管理这些潜在的严重并发症至关重要.

科学领域:

  • 在瘤学瘤学.
  • 免疫学 免疫学 免疫学
  • 神经学 神经学

背景情况:

  • 布罗利祖马布是一种免疫检查点抑制剂,用于转移性尿路细胞癌.
  • 虽然它是有效的,但它会带来与免疫相关的不良事件 (irAEs) 的风险.
  • 从其他条件区分IRAEs可能是具有挑战性的.

研究的目的:

  • 报告一个病例的严重的irAEs模仿肌痛性肌痛症在一个患者治疗 pembrolizumab.
  • 要突出诊断难度在区分ICI诱导的肌肉炎从严重肌痛症.
  • 强调警监测和积极治疗IRAEs的重要性.

主要方法:

  • 一个77岁的女性患者的病例报告,患有尿路细胞癌,接受了 pembrolizumab 的治疗.
  • 临床表现为严重的双边死,肌炎和心肌炎.
  • 用高剂量类固醇和血交换进行诊断评估和治疗.

主要成果:

  • 患者出现了,肌炎和心肌炎,最初被怀疑是3M综合征,但后来被确定为模仿肌痛严重症.
  • 用高剂量类固醇和血交换成功治疗导致显著改善.
  • 这个案例强调了ICI引起的并发症的诊断挑战.
关键词:
眼的结核病是眼的结核病.高剂量的类固醇.免疫检查点抑制剂 (ICI)免疫相关的不良事件 (IRAE)凯特鲁达诱导的肌肉炎骨髓灰质炎 (myesthenia gravis) 是一个严重的疾病.神经肌肉结合障碍 神经肌肉结合障碍血交换疗法是一种血交换疗法.

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Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin

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Last Updated: Jun 5, 2025

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Performing Human Skeletal Muscle Xenografts in Immunodeficient Mice
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Performing Human Skeletal Muscle Xenografts in Immunodeficient Mice

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Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin
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Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin

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结论:

  • 在接受pembrolizumab的患者中,对像ptosis,myositis和心肌炎这样的irAEs进行警监测至关重要.
  • 迅速和积极的治疗,包括类固醇和血交换,可以带来有利的结果.
  • 这一案例强调了在免疫检查点抑制剂治疗的背景下,需要仔细区分肌肉炎和肌肉炎.