在失眠障碍中将肠道微生物群,口腔微生物群和血清代谢物联系起来:一项初步研究
Weifeng Lin1,2, Yifan Yang3, Yurong Zhu4
1Department of Neurology, The Tenth Affiliated Hospital, Southern Medical University (Dongguan People's Hospital), Dongguan, Guangdong, 523000, People's Republic of China.
Nature and science of sleep
|December 12, 2024
概括
这项研究显示,在患有失眠障碍 (ID) 的人群中,肠道和口腔微生物群以及血清代谢物的显著变化. 这些变化与临床参数相关,表明微生物失生症,代谢物和失眠之间存在联系.
科学领域:
- 微生物组研究的研究.
- 代谢学 代谢学 代谢学
- 睡眠科学 睡眠科学
背景情况:
- 失眠障碍 (ID) 越来越多地与肠道微生物群的改变有关.
- 然而,关于肠道微生物群,口腔微生物群和ID中的血清代谢物之间的相互作用的全面研究是有限的.
研究的目的:
- 在患有失眠障碍 (ID) 的患者中调查和描述肠道微生物群,口腔微生物群和血清代谢物.
- 探索这些成分之间的相互作用,以及它们与ID的临床参数的相关性.
- 为了确定ID的潜在微生物生物标志物.
主要方法:
- 从76名ID患者和59名健康对照组 (HCs) 收集了便,口服和血清样本.
- 采用16S rDNA测序用于微生物群分析和非向的代谢基因组学,用于血清代谢物分析.
- 进行了多项omics分析以阐明相互作用和相关性.
主要成果:
- 在ID患者的肠道和口腔微生物群中观察到失生症.
- 鉴定出了明显的微生物特征,区分了ID患者和HC患者.
- 11个血清代谢物,包括腺,和硫酸盐,在组之间显示出显著的差异.
- 腺素与特定的细菌属和总睡眠时间正相关.
- 和硫酸盐与特定的细菌属和失眠严重程度指数相关.
结论:
- 在ID中改变的微生物群和血清代谢物与临床参数有显著的相关性,这表明有机械联系.
- 这项研究为肠道微生物群,口腔微生物群,血清代谢物和失眠障碍之间的复杂相互作用提供了新的见解.
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