在接受密集流体治疗的患有恶性疾病的儿童中,高NT亲BNP水平:一个前性比较研究
Weronika Pawlik1, Joanna Strzemecka1, Albert Stachura2
1Department of Pediatrics, Haemato-Oncology and Gastroenterology, Pomeranian Medical University, Szczecin, Poland.
Frontiers in pediatrics
|December 12, 2024
概括
在患有血液性恶性瘤的儿童中,强化液体治疗没有影响血压,但增加了NT-proBNP水平,这表明潜在的液体过载对心血管系统的影响.
科学领域:
- 心脏病学 心脏病学
- 儿科瘤学 儿科瘤学
- 血液学 血液学 血液学
背景情况:
- 血液性恶性瘤与心血管疾病风险增加有关.
- 化疗通常涉及密集的液体疗法 (IFT),可能损害心血管健康并增加高血压风险.
研究的目的:
- 评估IFT对心房内尿素 (NT-proBNP),高灵敏度Troponin T (hs-TnT) 和小儿血液恶性瘤患者的血压的影响.
- 在这个脆弱人群中评估心血管系统对IFT的反应.
主要方法:
- 对13名患有血液性恶性瘤的儿童进行IFT的前性队列研究.
- 24小时门诊血压监测 (ABPM) 和测量NT-proBNP和hs-TnT在基线,24小时进入IFT,并在随访期间.
主要成果:
- 没有观察到24小时,白天或夜间缩和腹缩血压的显著变化,也没有观察到IFT期间血压下降的模式.
- 与基线和随访相比,在IFT24小时后,NT-proBNP水平显著升高 (p<0.01).
- 高灵敏度的托罗邦素T水平在时间点之间没有显著差异.
结论:
- 在患有血液性恶性瘤的儿童中,强化液体治疗似乎不会显著影响血压.
- 在IFT后NT-proBNP水平升高表明流体过载对儿科心血管系统的潜在影响.
- 需要进一步的研究,以了解IFT对这些患者的长期心血管影响.
相关概念视频
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
57
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
57
01:27Parentral Nutrition: Centeral and Peripheral Parental Nutrition
101
Parenteral Nutrition (PN) delivers essential nutrients directly into the bloodstream, bypassing the digestive system. It is commonly used for individuals with severe digestive disorders or conditions that prevent normal nutrient absorption.
PN can be administered through two primary routes:
1. Central Parenteral Nutrition (CPN):
CPN involves delivering a high concentration of nutrients through a large vein. This is typically achieved using a Peripherally Inserted Central Catheter (PICC) or,...
PN can be administered through two primary routes:
1. Central Parenteral Nutrition (CPN):
CPN involves delivering a high concentration of nutrients through a large vein. This is typically achieved using a Peripherally Inserted Central Catheter (PICC) or,...
101