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生物钟基因BMAL1调节狼的自身免疫特征

Shuichiro Nakabo1, Donavon Sandoval-Heglund1, Norio Hanata1

  • 1Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, United States.

Frontiers in immunology
|December 12, 2024
PubMed
概括

大脑和肌肉的基碳化合物受体核转位器样1 (Bmal1) 缺陷中性粒细胞加剧了小鼠的狼性炎. 人类SLE中性粒细胞中的Bmal1水平与疾病活性相关,这表明昼夜节律在狼病变发生过程中起着作用.

关键词:
4月 4月 4月 4月 4月 4月 4月 4月 4月Bmal1 的意思是什么?自动抗体是一种自身抗体.时钟基因的时间中性粒细胞中性粒细胞.系统性红血性狼 (Systemic Lupus Erythematosus) 是一种全身性狼.

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