用于水溶性较差的药物的溶化技术
Bing Xie1, Yaping Liu1, Xiaotong Li1
1School of Pharmacy, China Pharmaceutical University, Nanjing 2111198, China.
Acta pharmaceutica Sinica. B
|December 12, 2024
概括
提高水溶性较差的药物的可溶性对于药物开发至关重要. 本综述探讨了包括载体和结晶在内的各种技术,以提高药物的溶解性和生物可用性.
科学领域:
- 制药科学 制药科学
- 药物运输 药物运输 药物运输
- 药用化学 医学化学
背景情况:
- 大约40%的批准药物和90%的候选药物具有较差的水溶性.
- 低溶解度显著限制了药物的有效性和生物可用性,这在药物开发中构成了重大挑战.
- 解决水溶性差的问题对于推动药物开发和治疗应用至关重要.
研究的目的:
- 为水溶性较差的药物提供常规和先进的溶解技术的全面概述.
- 详细介绍各种可溶性增强策略的机制,最近的进展和临床翻译潜力.
- 引导选择合适的溶解方法,剂量形式和适用于水溶性较差药物的施用途径.
主要方法:
- 常规溶解技术的审查:溶解剂,水,辅溶剂,前期药物,盐改性,微缩,环氧含量和固体分散.
- 详细检查先进的策略:结晶,离子液体和基于聚合物,基于脂质和基于无机的载体.
- 已批准的载体材料和在水溶性较差的药物中成功应用的总结.
主要成果:
- 传统和先进的技术提供了各种机制来提高药物的溶解性和生物可用性.
- 几种载体材料和药物配方已经证明了成功的临床转化.
- 新兴技术显示出克服可溶性挑战的重大前景.
结论:
- 有效的溶解是释放水溶性较差药物的治疗潜力的关键.
- 选择溶解技术的系统方法,考虑到药物的特性和预期用途,是必不可少的.
- 对新型药物输送系统的持续研究和开发对于解决水溶性较差药物的未满足需求至关重要.
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