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Updated: Jul 15, 2026

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发现了针对来自海洋天然产品的乙型肝炎病毒核心蛋白的新型小分子,使用基于HiBiT的高通量查

Chao Huang1,2, Yang Jin2,3, Panpan Fu3

  • 1Key Laboratory of Medical Molecular Virology (MOE/NHC), Research Unit of Cure of Chronic Hepatitis B Virus Infection (CAMS), Shanghai Frontiers Science Center of Pathogenic Microbes and Infection, School of Basic Medical Sciences, Shanghai Medical College Fudan University, Shanghai 200032, China.

Acta pharmaceutica Sinica. B
|December 12, 2024
PubMed
概括

从海洋化合物中发现了新的乙型肝炎病毒 (HBV) 核心蛋白组合调节器 (CpAM). 化合物11a具有强大的抗HBV活性,并与现有疗法产生协同作用,提供了一个有前途的新治疗策略.

关键词:
这是一种抗HBVV的药物.由生物活性驱动的合成.核心蛋白质组合调节器 核心蛋白质组合调节器肝炎病毒核心蛋白质是HBV的核心蛋白质.这就是HiBiTT的意思.的化合物 的化合物海洋天然产品 海洋天然产品纳米丁 J 的衍生品.

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