儿童群体中的红细胞合免疫和自身免疫:中国中部地区的多中心,横截面研究
Yongjun Wang1, Yuanqing Yang1, Zhengfeng Li2
1Department of Blood Transfusion, The Second Xiangya Hospital, Central South University, Changsha, China.
概括
在中国儿童中,红细胞配免疫的患病率为0.55%,自身免疫的患病率为0.14%. 抗M抗体是最常见的,重复输血前检测可以省略在4个月以下的婴儿.
科学领域:
- 血液学 血液学 血液学
- 免疫学 免疫学 免疫学
- 儿科 儿科 儿科
背景情况:
- 红细胞附抗体和自身抗体构成了输血方面的挑战.
- 此前,中国儿童中这些抗体的患病率数据缺乏.
研究的目的:
- 确定中国儿科患者的红细胞合免疫和自身免疫的患病率.
- 为中国儿童的输血管理政策提供信息.
主要方法:
- 分析了来自中国中部三个三级医院的30603名儿科住院患者的数据.
- 用于抗体查和识别面板的柱结合技术.
- 收集临床细节以确定抗体形成的危险因素.
主要成果:
- 同免疫率为0.55%,自免疫率为0.14%.
- 抗M (58.77%) 是最常见的抗体;自身抗体占19.91%.
- 年龄,性别,地理位置,ABO血型和诊断是抗体形成的重要风险因素.
结论:
- 由于抗体形成的零风险,可以在婴儿<4个月时省略重复输血前测试.
- 在较小的儿童中,MNS系统抗体 (特别是抗M) 普遍存在.
- 需要扩展Rh系统抗原匹配输血;共享输血记录对于预防溶血反应至关重要.
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