轻度COVID-19对中期呼吸功能的影响
J van Heerden1,2, H Strijdom2, A Parker3
1Division of Pulmonology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University and Tygerberg Hospital, Cape Town, South Africa.
轻微的COVID-19可能导致持久的呼吸系统问题,特别是肺部扩散能力降低,即使在没有寻求医疗保健的人中也是如此. 较高的体重指数 (BMI) 与感染后肺功能结果较差有关.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 传染性疾病 传染性疾病
- 肺部病理学 肺部病理学
背景情况:
- 在不寻求医疗护理的个人中,对轻度COVID-19的呼吸系统影响的证据有限.
- 轻微的SARS-CoV-2感染可能会对肺功能产生未被诊断的中期影响.
研究的目的:
- 评估轻度COVID-19对非寻求医疗保健的个体呼吸功能的影响.
- 为了确定轻度SARS-CoV-2感染后肺功能下降的预测因素.
主要方法:
- 对175名确诊轻度COVID-19的个体进行横截面研究.
- 肺功能测试 (PFTs),包括精神测量和肺部对一氧化碳 (DLCO) 的扩散能力,在感染后的6,12和24个月进行.
- 还进行了6分钟步行距离 (6MWD) 测试.
主要成果:
- 减少的DLCO是最常见的异常 (57%),表明气体交换受损.
- 螺旋计显示了阻塞性 (10%) 和限制性 (13%) 损伤.
- 增加的BMI与较低的PFT结果和6MWD显著相关.
结论:
- 轻度的COVID-19可能导致肺功能持续下降,特别是DLCO,感染后长达两年.
- 高BMI是轻度SARS-CoV-2感染后呼吸功能和运动能力下降的独立风险因素.
- 即使是轻微的COVID-19病例也需要考虑潜在的长期呼吸系统后果.
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