乙烯氧化物暴露与生物衰老加速之间的关联:来自NHANES 2013-2016年的证据
Xinyun Chen1, Fangyu Shi1, Wenhui Yu2
1Department of Health Management, Health Management Center, General Practice Center, West China Hospital, Sichuan University, Chengdu, China.
Frontiers in public health
|December 12, 2024
概括
暴露于乙烯氧化物 (EO) 与加速的生物衰老有关. 这项研究发现,较高的EO水平与更快的衰老相关,强调需要对这一环境健康问题进行进一步研究.
科学领域:
- 环境健康 环境健康
- 老年学是一门学科.
- 毒理学 毒理学 毒理学
背景情况:
- 全球人口老龄化带来了重大的公共卫生挑战.
- 乙烯氧化物 (EO) 是一种具有已知的健康风险的工业化学物质,可能与与年龄相关的疾病有关.
- 了解加速生物衰老的环境暴露至关重要.
研究的目的:
- 调查乙烯氧化物 (EO) 暴露与生物衰老加速之间的关联.
- 为了确定EO暴露是否有助于比时间表年龄更快的衰老.
主要方法:
- 分析了NHANES 2013-2016年调查的3155名参与者的数据.
- 通过血红蛋白添加物 (HbEO) 测量血液中EO水平.
- 使用表型年龄加速 (PhenoAgeAccel) 和克莱梅拉-双方法年龄加速 (KDM-AA) 评估生物衰老加速,并进行回归分析.
主要成果:
- 更高的EO暴露与增加的PhenoAgeAccel和KDM-AA.AA显著相关.
- 观察到一种剂量反应关系,较高的EO水平与更大的生物衰老加速有关.
- 亚组分析表明,BMI,性别和糖尿病状况等因素会改变这种关联.
结论:
- 乙烯氧化物暴露与加速的生物衰老有显著的关联.
- 这些发现强调了环境毒素对衰老过程的潜在影响.
- 需要进一步的前性和机制性研究来证实和阐明这些关联.
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