相关实验视频

Updated: Jun 5, 2025

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

Published on: January 22, 2018

双A和双S暴露与FDG PET/CT图像上的代谢参数的相关性

Liu Xiao¹, Xue Wen², Lin Li¹

¹Department of Nuclear Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, China.

Frontiers in public health

|December 12, 2024

概括

双A (BPA) 和双S (BPS) 暴露会影响器官新陈代谢. 这项研究使用18F-FDG PET/CT将BPA和BPS水平与肝脏,甲状腺和大脑组织的代谢变化联系起来.

科学领域:

内分泌学在内分泌学.
毒理学毒理学毒理学
核医学就是核医学.

背景情况:

双A (BPA) 和它的类似物是具有已知的不良健康影响的内分泌干扰化学物质.
双S (BPS) 是一种常见的BPA替代品,引发了人们对其自身毒性的担忧.
评估这些化合物对人体器官的代谢影响对于了解它们的健康风险至关重要.

研究的目的:

调查尿中双A (BPA) 和双S (BPS) 水平与组织代谢参数之间的相关性.
使用18F-氧葡萄糖正子发射断层扫描/计算机断层扫描 (18F-FDG PET/CT) 成像来评估关键器官的代谢活动.
为了确定受BPA和BPS暴露影响的特定器官系统.

主要方法:

对具有可用的18F-FDG PET/CT成像和尿液BPA/BPS测量患者的回顾性分析.
在肝脏,血液,脏,肌肉,甲状腺和大脑皮层中量化标准化摄入值 (SUVmax和SUVmean).
斯皮尔曼的等级相关性分析,以评估BPA/BPS度与SUV值之间的关系.

主要成果:

在男性中,尿液BPA与肝脏代谢活性 (SUVmax/平均值) 有中度正相关性.
在男性中,尿液BPS与甲状腺代谢活性 (SUVmax/平均值) 呈负相关性.
在女性中,观察到BPS和大脑皮层代谢活性 (SUVmax) 之间存在正相关性.

结论:

尿液中的BPA和BPS水平与组织代谢参数的明显变化有关.
肝脏,甲状腺和大脑皮层受到BPA和BPS暴露的影响.
FDG PET/CT成像为可视化双暴露的代谢后果提供了有价值的工具.

关键词:

BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA 在BPS中,BPS是BPS.德国联邦航空公司 (FDG)肝脏SUVmaxSUVmax 的时间甲状腺SUVmax 的

更多相关视频

Determining Glucose Metabolism Kinetics Using 18F-FDG Micro-PET/CT

Determining Glucose Metabolism Kinetics Using 18F-FDG Micro-PET/CT

Published on: May 2, 2017

Functional Imaging of Brown Fat in Mice with 18F-FDG micro-PET/CT

Functional Imaging of Brown Fat in Mice with 18F-FDG micro-PET/CT

Published on: November 23, 2012

相关概念视频

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET

Positron Emission Tomography

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...