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协生补充剂对肥胖和肥胖成年人肠道微生物群的影响:双盲随机对照试验

Xiaokang Niu¹, Qi Zhang², Julong Liu³

¹Key Laboratory of Functional Dairy, Co-Constructed by Ministry of Education and Beijing Government, Department of Nutrition and Health, China Agricultural University, Beijing, China.

Frontiers in nutrition

|December 12, 2024

概括

在肥胖的人群中,合成生物补充剂有效降低了身体脂肪和LDL胆固醇. 这种干预也积极改变了肠道微生物群和荷尔蒙水平,表明了一种有希望的治疗方法.

科学领域:

微生物学微生物学
营养科学营养科学
胃肠病学胃肠病学

背景情况:

协生菌是一种益生菌和益生菌的组合,显示出管理与肥胖有关的健康问题的潜力,尽管现有研究提出了不一致的发现.
本研究中使用的特定共生菌配方包括*Bifidobacterium animalis*亚种. *乳糖* MN-Gup,银寡糖化物 (GOS) 和氧寡糖化物 (XOS).

研究的目的:

评估预先选的共生组合在人类人口中控制肥胖的疗效.
调查协生菌对肥胖个体的身体组成,代谢标记物和肠道微生物群的影响.

主要方法:

一个随机,双盲,安慰剂控制的试验,涉及80名肥胖参与者.
每天服用共生药物 (MN-Gup,GOS,XOS) 或安慰剂12周,并进行全面的干预前后测量.

主要成果:

协生菌显著降低了体脂百分比,腰围和血清低密度脂蛋白胆固醇 (LDL-C).
这种干预导致了和激素 (YY,胆囊托基宁,氧托莫杜林) 和抗氧化酶 (氨酸过氧化酶) 的水平增加.
协生菌的使用丰富了有益的肠道细菌,并增加了陈诺二氧化醇酸 (CDCA) 水平,在*Bifidobacterium*,*Romboutsia*和CDCA之间存在正相关性.

结论:

12周的协生菌干预有效降低了主要肥胖指标,改善了脂质概况,特别是在并发性脂质不良症患者中.
观察到的好处很可能是由肠道微生物群,胆酸代谢和肠道激素分泌的变化引起的.

关键词:

生物细菌 (Bifidobacterium animalis) 的亚种. 乳糖公司MN-Gup 我们的肠道微生物群.肥胖肥胖肥胖肥胖肥胖肥胖肥胖肥胖随机对照试验是随机对照试验.综合生物 synbiotics 综合生物

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