通过[18F]ALF-NOTA-FAPI-04 PET/CT成像进行IgA脏病严重程度的非侵入性评估
Hao Wang1, Limeng He1, Lijuan Feng1
1Department of Nuclear Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu Sichuan, China.
[18F]ALF-NOTA-FAPI-04 PET/CT成像显示,免疫球蛋白A脏病 (IgAN) 患者的纤维细胞激活蛋白抑制剂吸收率较高. 这种非侵入性方法与疾病严重程度相关,可以监测IgAN进展.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 核医学是一种核医学.
- 放射化学 放射化学是指辐射化学.
背景情况:
- 脏活检是诊断和分期免疫球蛋白A脏病 (IgAN) 的侵入性.
- 需要使用非侵入性方法来评估IGAN病理.
- 纤维细胞激活蛋白 (FAP) 与纤维性疾病有关.
研究的目的:
- 评估AlF-NOTA-FAPI-04正子发射断层扫描/计算机断层扫描 (PET/CT) 在识别Igan相关的病理变化的实用性.
- 为了将FAP成像发现与IGAN严重性的组织学标志物相关联.
主要方法:
- 20名新诊断的Igan患者和10名对照患者接受了AlF-NOTA-FAPI-04 PET/CT.
- 用牛津分类的免疫光学和免疫组织化学分析脏活检样本,α-平滑肌动蛋白 (αSMA) 和FAP表达.
- 脏FAPI吸收的标准化吸收值 (SUVmax和SUVmean) 与组织学发现相关.
主要成果:
- 与对照组相比,Igan患者的脏FAPI吸收量 (SUVmax,SUV平均值) 显著增加 (P < .001).
- 脏FAPI吸收与间歇性纤维化,管状缩和管状间歇性炎症评分 (P < .05) 有积极的相关性.
- FAPI的摄入也显示出与球和管间的αSMA和FAP表达的显著正相关性 (P < .01).
结论:
- [18F]ALF-NOTA-FAPI-04 PET/CT是IGAN的一种有前途的非侵入性成像技术.
- 影像成像方式可以反映病变的程度和疾病的活性.
- 这种方法可以作为监测IGAN进展的宝贵工具.
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