孕期糖尿病和儿童早期的线性生长
Zi-Lin Chen1,2, Xin Liu1, Min-Yi Tao1
1Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Early Life Health Institute, and Department of Pediatrics, Xinhua Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, China.
Frontiers in endocrinology
|December 12, 2024
概括
母亲的孕期糖尿病 (GDM) 与儿童在幼儿时期的线性生长减少有关. 这项研究发现,从出生到四岁暴露于GDM的后代在年龄Z分数的高度上存在一致的缺陷.
科学领域:
- 儿科 儿科 儿科
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 孕期糖尿病 (GDM) 是一种普遍存在的妊娠并发症,对母亲和胎儿都有已知的风险.
- 由于研究有限且相互矛盾,GDM对后代长期线性生长的影响仍然不完全理解.
- 了解GDM对儿童发育的影响对于早期干预和改善健康结果至关重要.
研究的目的:
- 调查母亲的GDM与儿童在幼儿时期的纵向线性生长之间的联系.
- 量化GDM暴露对出生至4岁的身高对年龄Z分数 (HAZ) 的影响.
主要方法:
- 上海的一项前性出生队列研究包括2055名儿童,其中369名出生于患有GDM的母亲.
- 在多个时间点测量儿童的长度/身高:出生,6周,6个月,1,2,4岁.
- 使用多变量回归和概括估计方程模型来分析GDM对HAZ的影响.
主要成果:
- 患有GDM和没有GDM的母亲生下的婴儿的平均出生长度相似.
- 在对共变量进行调整后,患有GDM的母亲的孩子在所有测量年龄段 (6周至4岁) 均表现出持续较低的HAZ得分.
- 母亲GDM与从出生到4岁的HAZ生长轨迹中的0.12个缺陷有关.
结论:
- GDM与幼儿时期的纵向线性生长受损有关.
- 这些发现表明GDM对后代的身体发育有不利影响.
- 需要进一步的研究来探索GDM对身材和整体健康的长期影响.
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