子宫内膜和脂肪内治疗 - 没有一般建议
Paolina Mrosk1,2, Nathallie Sandi-Monroy1,3, Friedrich Gagsteiger1,4
1Kinderwunschzentrum Ulm, Ulm, Germany.
Frontiers in reproductive health
|December 12, 2024
概括
子宫内膜和脂质内治疗并没有提高试管婴儿成功率. 这些附加疗法在超过2800个周期的回顾性研究中没有显著影响怀孕或活产率.
科学领域:
- 生殖医学 生殖医学
- 不孕症治疗方法 不孕症治疗方法
- 辅助生殖技术 (ART) 是一种辅助生殖技术.
背景情况:
- 子宫内膜 (ES) 和静脉内脂治疗被用作ART的附加治疗.
- 支持这些干预措施有效性的证据,特别是对子宫自然杀手细胞 (uNKs) 的增加,仍然有限.
研究的目的:
- 评估ES或脂质内疗法与IVF/ICSI接受患者的怀孕/活产率之间的关联.
- 确定这些附加疗法在新鲜或冷胚胎移植周期中是否有好处.
主要方法:
- 在2014-2017年间,对1546名患者的2821次试管婴儿/ICSI周期进行了回顾性分析.
- 怀孕和活产率的比较在有和没有ES的周期中.
- 多变量通用估计方程 (GEE) 模型被用于计算每个患者的多个周期.
主要成果:
- 在第一和随后的治疗周期中,在ES和无ES周期之间没有观察到怀孕或活产率的统计学上显著差异.
- GEE模型证实ES对怀孕 (p=0.449) 或活产率 (p=0.976) 没有显著的影响.
- 内脂治疗也没有显著影响怀孕 (p=0.926) 或活产率 (p=0.727).
结论:
- 该研究没有发现任何证据表明子宫内膜痕改善了IVF/ICSI接受女性的怀孕或活产率.
- 内部脂质治疗也被发现没有益处.
- 这些程序在临床研究之外不推,因为缺乏已证明的益处.
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