纤维肌痛的严重程度和症状与肠-大脑相互作用障碍有关
Sharon Erdrich1, Joanna E Harnett1
1School of Pharmacy, Faculty of Medicine and Health, The University of Sydney, Camperdown, New South Wales, Australia.
European journal of pain (London, England)
|December 12, 2024
概括
纤维肌痛患者经常有多种肠-大脑相互作用障碍 (DGBI),超出IBS. 这些DGBI与增加的疼痛,纤维肌痛严重程度和睡眠问题相关,突出显示需要综合护理.
科学领域:
- 胃肠病学 胃肠病学
- 类风湿病学 类风湿病学
- 神经科学是一个神经科学.
背景情况:
- 纤维肌痛是一种常见的特异性疾病,引起广泛的疼痛,没有明确的治疗方法.
- 刺激性肠综合征 (IBS) 在纤维肌痛患者中很常见,但其他肠脑相互作用障碍 (DGBI) 的研究较少.
- 各种DGBI对纤维肌痛症状的患病率和影响仍然不清楚.
研究的目的:
- 确定患有纤维肌痛的女性中广泛的DGBI的流行率.
- 研究DGBI与纤维肌痛症状严重程度 (包括疼痛和睡眠质量) 之间的关联.
主要方法:
- 在新西兰进行的一项前性观察研究.
- 通过全面的调查,利用罗马四号标准来确定DGBI.
- 评估了纤维肌痛的严重程度,疼痛,睡眠,生活质量,心理健康和偏头痛.
主要成果:
- 在111名患有纤维肌痛的女性中,93%至少有一次DGBI;68%患有多次DGBI.
- 所有DGBI组和11个特定的DGBI都与疼痛,纤维肌痛严重程度,睡眠问题和偏头痛 (p <0.05) 有显著的关联.
- 纤维肌痛症状的严重程度,包括睡眠问题,与功能性肠道疾病的严重程度相关.
结论:
- 在患有纤维肌痛的女性中,DGBI非常普遍,超出IBS.
- 多重DGBI的存在与疼痛增加,纤维肌痛严重程度和睡眠障碍有关.
- 解决DGBI对于管理纤维肌痛症状和改善患者福祉至关重要.
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